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Actual survival after resection of primary colorectal cancer: results from a prospective multicenter study

BACKGROUND: Colorectal cancer is the third most common type of cancer in the world. We characterize a cohort of patients who survived up to 5 years without recurrence and identify factors predicting the probability of cure. METHODS: We analyzed data of patients who underwent curative intent surgery...

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Autores principales: van den Berg, Inge, Coebergh van den Braak, Robert R. J., van Vugt, Jeroen L. A., Ijzermans, Jan N. M., Buettner, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8022415/
https://www.ncbi.nlm.nih.gov/pubmed/33820567
http://dx.doi.org/10.1186/s12957-021-02207-4
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author van den Berg, Inge
Coebergh van den Braak, Robert R. J.
van Vugt, Jeroen L. A.
Ijzermans, Jan N. M.
Buettner, Stefan
author_facet van den Berg, Inge
Coebergh van den Braak, Robert R. J.
van Vugt, Jeroen L. A.
Ijzermans, Jan N. M.
Buettner, Stefan
author_sort van den Berg, Inge
collection PubMed
description BACKGROUND: Colorectal cancer is the third most common type of cancer in the world. We characterize a cohort of patients who survived up to 5 years without recurrence and identify factors predicting the probability of cure. METHODS: We analyzed data of patients who underwent curative intent surgery for stage I–III CRC between 2007 and 2012 and who had had been included in a large multicenter study in the Netherlands. Cure was defined as 5-year survival without recurrence. Survival data were retrieved from a national registry. RESULTS: Analysis of data of 754 patients revealed a cure rate of 65% (n = 490). Patients with stage I disease and T1- and N0-tumor had the highest probability of cure (94%, 95% and 90%, respectively). Those with a T4-tumor or N2-tumor had the lowest probability of cure (62% and 50%, respectively). A peak in the mortality rate for older patients early in follow-up suggests early excess mortality as an explanation. A similar trend was observed for stage III disease, poor tumor grade, postoperative complications, sarcopenia, and R1 resections. Patients with stage III disease, poor tumor grade, postoperative complications, sarcopenia, and R1 resections show a similar trend for decrease in CSS deaths over time. CONCLUSION: In the studied cohort, the probability of cure for patients with stage I–III CRC ranged from 50 to 95%. Even though most patients will be cured from CRC with standard therapy, standard therapy is insufficient for those with poor prognostic factors, such as high T- and N-stage and poor differentiation grade.
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spelling pubmed-80224152021-04-07 Actual survival after resection of primary colorectal cancer: results from a prospective multicenter study van den Berg, Inge Coebergh van den Braak, Robert R. J. van Vugt, Jeroen L. A. Ijzermans, Jan N. M. Buettner, Stefan World J Surg Oncol Research BACKGROUND: Colorectal cancer is the third most common type of cancer in the world. We characterize a cohort of patients who survived up to 5 years without recurrence and identify factors predicting the probability of cure. METHODS: We analyzed data of patients who underwent curative intent surgery for stage I–III CRC between 2007 and 2012 and who had had been included in a large multicenter study in the Netherlands. Cure was defined as 5-year survival without recurrence. Survival data were retrieved from a national registry. RESULTS: Analysis of data of 754 patients revealed a cure rate of 65% (n = 490). Patients with stage I disease and T1- and N0-tumor had the highest probability of cure (94%, 95% and 90%, respectively). Those with a T4-tumor or N2-tumor had the lowest probability of cure (62% and 50%, respectively). A peak in the mortality rate for older patients early in follow-up suggests early excess mortality as an explanation. A similar trend was observed for stage III disease, poor tumor grade, postoperative complications, sarcopenia, and R1 resections. Patients with stage III disease, poor tumor grade, postoperative complications, sarcopenia, and R1 resections show a similar trend for decrease in CSS deaths over time. CONCLUSION: In the studied cohort, the probability of cure for patients with stage I–III CRC ranged from 50 to 95%. Even though most patients will be cured from CRC with standard therapy, standard therapy is insufficient for those with poor prognostic factors, such as high T- and N-stage and poor differentiation grade. BioMed Central 2021-04-05 /pmc/articles/PMC8022415/ /pubmed/33820567 http://dx.doi.org/10.1186/s12957-021-02207-4 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
van den Berg, Inge
Coebergh van den Braak, Robert R. J.
van Vugt, Jeroen L. A.
Ijzermans, Jan N. M.
Buettner, Stefan
Actual survival after resection of primary colorectal cancer: results from a prospective multicenter study
title Actual survival after resection of primary colorectal cancer: results from a prospective multicenter study
title_full Actual survival after resection of primary colorectal cancer: results from a prospective multicenter study
title_fullStr Actual survival after resection of primary colorectal cancer: results from a prospective multicenter study
title_full_unstemmed Actual survival after resection of primary colorectal cancer: results from a prospective multicenter study
title_short Actual survival after resection of primary colorectal cancer: results from a prospective multicenter study
title_sort actual survival after resection of primary colorectal cancer: results from a prospective multicenter study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8022415/
https://www.ncbi.nlm.nih.gov/pubmed/33820567
http://dx.doi.org/10.1186/s12957-021-02207-4
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