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Establishment of a new sex-determining allele driven by sexually antagonistic selection
The turnover of sex-determining loci has repeatedly occurred in a number of species, rather than having a diverged pair of sex chromosomes. We model the turnover process by considering a linked locus under sexually antagonistic selection. The entire process of a turnover may be divided into two phas...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8022746/ https://www.ncbi.nlm.nih.gov/pubmed/33561232 http://dx.doi.org/10.1093/g3journal/jkaa031 |
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author | Sakamoto, Takahiro Innan, Hideki |
author_facet | Sakamoto, Takahiro Innan, Hideki |
author_sort | Sakamoto, Takahiro |
collection | PubMed |
description | The turnover of sex-determining loci has repeatedly occurred in a number of species, rather than having a diverged pair of sex chromosomes. We model the turnover process by considering a linked locus under sexually antagonistic selection. The entire process of a turnover may be divided into two phases, which are referred to as the stochastic and deterministic phases. The stochastic phase is when a new sex-determining allele just arises and is still rare and random genetic drift plays an important role. In the deterministic phase, the new allele further increases in frequency by positive selection. The theoretical results currently available are for the deterministic phase, which demonstrated that a turnover of a newly arisen sex-determining locus could benefit from selection at a linked locus under sexually antagonistic selection, by assuming that sexually antagonistic selection works in a form of balancing selection. In this work, we provide a comprehensive theoretical description of the entire process from the stochastic phase to the deterministic phase. In addition to balancing selection, we explore several other modes of selection on the linked locus. Our theory allows us make a quantitative argument on the rate of turnover and the effect of the mode of selection at the linked locus. We also performed simulations to explore the pattern of polymorphism around the new sex-determining locus. We find that the pattern of polymorphism is informative to infer how selection worked through the turnover process. |
format | Online Article Text |
id | pubmed-8022746 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-80227462021-04-09 Establishment of a new sex-determining allele driven by sexually antagonistic selection Sakamoto, Takahiro Innan, Hideki G3 (Bethesda) Investigation The turnover of sex-determining loci has repeatedly occurred in a number of species, rather than having a diverged pair of sex chromosomes. We model the turnover process by considering a linked locus under sexually antagonistic selection. The entire process of a turnover may be divided into two phases, which are referred to as the stochastic and deterministic phases. The stochastic phase is when a new sex-determining allele just arises and is still rare and random genetic drift plays an important role. In the deterministic phase, the new allele further increases in frequency by positive selection. The theoretical results currently available are for the deterministic phase, which demonstrated that a turnover of a newly arisen sex-determining locus could benefit from selection at a linked locus under sexually antagonistic selection, by assuming that sexually antagonistic selection works in a form of balancing selection. In this work, we provide a comprehensive theoretical description of the entire process from the stochastic phase to the deterministic phase. In addition to balancing selection, we explore several other modes of selection on the linked locus. Our theory allows us make a quantitative argument on the rate of turnover and the effect of the mode of selection at the linked locus. We also performed simulations to explore the pattern of polymorphism around the new sex-determining locus. We find that the pattern of polymorphism is informative to infer how selection worked through the turnover process. Oxford University Press 2020-12-09 /pmc/articles/PMC8022746/ /pubmed/33561232 http://dx.doi.org/10.1093/g3journal/jkaa031 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of Genetics Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Investigation Sakamoto, Takahiro Innan, Hideki Establishment of a new sex-determining allele driven by sexually antagonistic selection |
title | Establishment of a new sex-determining allele driven by sexually antagonistic selection |
title_full | Establishment of a new sex-determining allele driven by sexually antagonistic selection |
title_fullStr | Establishment of a new sex-determining allele driven by sexually antagonistic selection |
title_full_unstemmed | Establishment of a new sex-determining allele driven by sexually antagonistic selection |
title_short | Establishment of a new sex-determining allele driven by sexually antagonistic selection |
title_sort | establishment of a new sex-determining allele driven by sexually antagonistic selection |
topic | Investigation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8022746/ https://www.ncbi.nlm.nih.gov/pubmed/33561232 http://dx.doi.org/10.1093/g3journal/jkaa031 |
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