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Dielectric relaxation model of human blood as a superposition of Debye functions with relaxation times following a Modified-Weibull distribution

Dielectric spectroscopy of the human blood is a powerful and convenient non-invasive testing technique that can be used to diagnose diseases such as diabetes and leukemia. One needs to consider rigorous experimental procedures and mathematical models to make the results of this type of test comparab...

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Autores principales: Sodhi, Charandeep Singh, Ozelim, Luan Carlos de Sena Monteiro, Rathie, Pushpa Narayan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8022844/
https://www.ncbi.nlm.nih.gov/pubmed/33851060
http://dx.doi.org/10.1016/j.heliyon.2021.e06606
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author Sodhi, Charandeep Singh
Ozelim, Luan Carlos de Sena Monteiro
Rathie, Pushpa Narayan
author_facet Sodhi, Charandeep Singh
Ozelim, Luan Carlos de Sena Monteiro
Rathie, Pushpa Narayan
author_sort Sodhi, Charandeep Singh
collection PubMed
description Dielectric spectroscopy of the human blood is a powerful and convenient non-invasive testing technique that can be used to diagnose diseases such as diabetes and leukemia. One needs to consider rigorous experimental procedures and mathematical models to make the results of this type of test comparable. The present paper will discuss previously published results to further investigate the statistical modeling of the dielectric properties of human blood. The analysis shows that previously published results were related to Modified Weibull (MW) distributions of relaxation times, not Gaussian distributions, as reported. This re-analysis prevents the ill definition of fitting parameters, making sure they present physically justifiable values. Besides, for fluids presenting a Modified Weibull distribution of relaxation times, novel exact and closed-form expressions for the real and imaginary parts of complex permittivities were obtained in terms of generalized hypergeometric functions. Also, a high accuracy approximation was built for the imaginary part of the complex permittivity, creating an easy-to-use alternative expression for practitioners. The new results are used to fit experimental results for human blood, showing that more robust estimators are built for the parameters involved, which can be used as thresholds to classify the dielectric behavior of blood as normal (healthy) or anomalous (sick).
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spelling pubmed-80228442021-04-12 Dielectric relaxation model of human blood as a superposition of Debye functions with relaxation times following a Modified-Weibull distribution Sodhi, Charandeep Singh Ozelim, Luan Carlos de Sena Monteiro Rathie, Pushpa Narayan Heliyon Research Article Dielectric spectroscopy of the human blood is a powerful and convenient non-invasive testing technique that can be used to diagnose diseases such as diabetes and leukemia. One needs to consider rigorous experimental procedures and mathematical models to make the results of this type of test comparable. The present paper will discuss previously published results to further investigate the statistical modeling of the dielectric properties of human blood. The analysis shows that previously published results were related to Modified Weibull (MW) distributions of relaxation times, not Gaussian distributions, as reported. This re-analysis prevents the ill definition of fitting parameters, making sure they present physically justifiable values. Besides, for fluids presenting a Modified Weibull distribution of relaxation times, novel exact and closed-form expressions for the real and imaginary parts of complex permittivities were obtained in terms of generalized hypergeometric functions. Also, a high accuracy approximation was built for the imaginary part of the complex permittivity, creating an easy-to-use alternative expression for practitioners. The new results are used to fit experimental results for human blood, showing that more robust estimators are built for the parameters involved, which can be used as thresholds to classify the dielectric behavior of blood as normal (healthy) or anomalous (sick). Elsevier 2021-03-26 /pmc/articles/PMC8022844/ /pubmed/33851060 http://dx.doi.org/10.1016/j.heliyon.2021.e06606 Text en © 2021 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Research Article
Sodhi, Charandeep Singh
Ozelim, Luan Carlos de Sena Monteiro
Rathie, Pushpa Narayan
Dielectric relaxation model of human blood as a superposition of Debye functions with relaxation times following a Modified-Weibull distribution
title Dielectric relaxation model of human blood as a superposition of Debye functions with relaxation times following a Modified-Weibull distribution
title_full Dielectric relaxation model of human blood as a superposition of Debye functions with relaxation times following a Modified-Weibull distribution
title_fullStr Dielectric relaxation model of human blood as a superposition of Debye functions with relaxation times following a Modified-Weibull distribution
title_full_unstemmed Dielectric relaxation model of human blood as a superposition of Debye functions with relaxation times following a Modified-Weibull distribution
title_short Dielectric relaxation model of human blood as a superposition of Debye functions with relaxation times following a Modified-Weibull distribution
title_sort dielectric relaxation model of human blood as a superposition of debye functions with relaxation times following a modified-weibull distribution
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8022844/
https://www.ncbi.nlm.nih.gov/pubmed/33851060
http://dx.doi.org/10.1016/j.heliyon.2021.e06606
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