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LI Detector: a framework for sensitive colony-based screens regardless of the distribution of fitness effects

Microbial growth characteristics have long been used to investigate fundamental questions of biology. Colony-based high-throughput screens enable parallel fitness estimation of thousands of individual strains using colony growth as a proxy for fitness. However, fitness estimation is complicated by s...

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Detalles Bibliográficos
Autores principales: Parikh, Saurin Bipin, Castilho Coelho, Nelson, Carvunis, Anne-Ruxandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8022918/
https://www.ncbi.nlm.nih.gov/pubmed/33693606
http://dx.doi.org/10.1093/g3journal/jkaa068