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LI Detector: a framework for sensitive colony-based screens regardless of the distribution of fitness effects
Microbial growth characteristics have long been used to investigate fundamental questions of biology. Colony-based high-throughput screens enable parallel fitness estimation of thousands of individual strains using colony growth as a proxy for fitness. However, fitness estimation is complicated by s...
Autores principales: | Parikh, Saurin Bipin, Castilho Coelho, Nelson, Carvunis, Anne-Ruxandra |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8022918/ https://www.ncbi.nlm.nih.gov/pubmed/33693606 http://dx.doi.org/10.1093/g3journal/jkaa068 |
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