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Revisiting the genome-wide significance threshold for common variant GWAS
Over the last decade, GWAS meta-analyses have used a strict P-value threshold of 5 × 10(−8) to classify associations as significant. Here, we use our current understanding of frequently studied traits including lipid levels, height, and BMI to revisit this genome-wide significance threshold. We comp...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8022962/ https://www.ncbi.nlm.nih.gov/pubmed/33585870 http://dx.doi.org/10.1093/g3journal/jkaa056 |