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Natural compounds as inhibitors of SARS-CoV-2 endocytosis: A promising approach against COVID-19
BACKGROUND AND AIM: The recent COVID-19 pandemic caused by SARS-CoV-2 affected more than six million people and caused thousands of deaths. The lack of effective drugs or vaccines against SARS-CoV-2 further worsened the situation. This review is focused on the identification of molecules that may in...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Mattioli 1885
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8023130/ https://www.ncbi.nlm.nih.gov/pubmed/33170174 http://dx.doi.org/10.23750/abm.v91i13-S.10520 |
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author | Kiani, Aysha Karim Dhuli, Kristjana Anpilogov, Kyrylo Bressan, Simone Dautaj, Astrit Dundar, Munis Beccari, Tommaso Ergoren, Mahmut C. Bertelli, Matteo |
author_facet | Kiani, Aysha Karim Dhuli, Kristjana Anpilogov, Kyrylo Bressan, Simone Dautaj, Astrit Dundar, Munis Beccari, Tommaso Ergoren, Mahmut C. Bertelli, Matteo |
author_sort | Kiani, Aysha Karim |
collection | PubMed |
description | BACKGROUND AND AIM: The recent COVID-19 pandemic caused by SARS-CoV-2 affected more than six million people and caused thousands of deaths. The lack of effective drugs or vaccines against SARS-CoV-2 further worsened the situation. This review is focused on the identification of molecules that may inhibit viral entry into host cells by endocytosis. METHODS: We performed the literature search for these natural compounds in the articles indexed in PubMed. RESULTS: Natural products against viral infections have been gaining importance in recent years. Specific natural compounds like phytosterols, polyphenols, flavonoids, citrus, galangal, curcuma and hydroxytyrosol are being analyzed to understand whether they could inhibit SARS-CoV-2. CONCLUSIONS: We reviewed natural compounds with potential antiviral activity against SARS-CoV-2 that could be used as a treatment for COVID-19. (www.actabiomedica.it) |
format | Online Article Text |
id | pubmed-8023130 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Mattioli 1885 |
record_format | MEDLINE/PubMed |
spelling | pubmed-80231302021-04-07 Natural compounds as inhibitors of SARS-CoV-2 endocytosis: A promising approach against COVID-19 Kiani, Aysha Karim Dhuli, Kristjana Anpilogov, Kyrylo Bressan, Simone Dautaj, Astrit Dundar, Munis Beccari, Tommaso Ergoren, Mahmut C. Bertelli, Matteo Acta Biomed Original Article BACKGROUND AND AIM: The recent COVID-19 pandemic caused by SARS-CoV-2 affected more than six million people and caused thousands of deaths. The lack of effective drugs or vaccines against SARS-CoV-2 further worsened the situation. This review is focused on the identification of molecules that may inhibit viral entry into host cells by endocytosis. METHODS: We performed the literature search for these natural compounds in the articles indexed in PubMed. RESULTS: Natural products against viral infections have been gaining importance in recent years. Specific natural compounds like phytosterols, polyphenols, flavonoids, citrus, galangal, curcuma and hydroxytyrosol are being analyzed to understand whether they could inhibit SARS-CoV-2. CONCLUSIONS: We reviewed natural compounds with potential antiviral activity against SARS-CoV-2 that could be used as a treatment for COVID-19. (www.actabiomedica.it) Mattioli 1885 2020 2020-11-09 /pmc/articles/PMC8023130/ /pubmed/33170174 http://dx.doi.org/10.23750/abm.v91i13-S.10520 Text en Copyright: © 2020 ACTA BIO MEDICA SOCIETY OF MEDICINE AND NATURAL SCIENCES OF PARMA http://creativecommons.org/licenses/by-nc-sa/4.0 This work is licensed under a Creative Commons Attribution 4.0 International License |
spellingShingle | Original Article Kiani, Aysha Karim Dhuli, Kristjana Anpilogov, Kyrylo Bressan, Simone Dautaj, Astrit Dundar, Munis Beccari, Tommaso Ergoren, Mahmut C. Bertelli, Matteo Natural compounds as inhibitors of SARS-CoV-2 endocytosis: A promising approach against COVID-19 |
title | Natural compounds as inhibitors of SARS-CoV-2 endocytosis: A promising approach against COVID-19 |
title_full | Natural compounds as inhibitors of SARS-CoV-2 endocytosis: A promising approach against COVID-19 |
title_fullStr | Natural compounds as inhibitors of SARS-CoV-2 endocytosis: A promising approach against COVID-19 |
title_full_unstemmed | Natural compounds as inhibitors of SARS-CoV-2 endocytosis: A promising approach against COVID-19 |
title_short | Natural compounds as inhibitors of SARS-CoV-2 endocytosis: A promising approach against COVID-19 |
title_sort | natural compounds as inhibitors of sars-cov-2 endocytosis: a promising approach against covid-19 |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8023130/ https://www.ncbi.nlm.nih.gov/pubmed/33170174 http://dx.doi.org/10.23750/abm.v91i13-S.10520 |
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