Cargando…
TNB-486 induces potent tumor cell cytotoxicity coupled with low cytokine release in preclinical models of B-NHL
The therapeutic potential of targeting CD19 in B cell malignancies has garnered attention in the past decade, resulting in the introduction of novel immunotherapy agents. Encouraging clinical data have been reported for T cell-based targeting agents, such as anti-CD19/CD3 bispecific T-cell engager b...
Autores principales: | Malik-Chaudhry, Harbani K., Prabhakar, Kirthana, Ugamraj, Harshad S., Boudreau, Andrew A., Buelow, Benjamin, Dang, Kevin, Davison, Laura M., Harris, Katherine E., Jorgensen, Brett, Ogana, Heather, Pham, Duy, Schellenberger, Ute, Van Schooten, Wim, Buelow, Roland, Iyer, Suhasini, Trinklein, Nathan D., Rangaswamy, Udaya S. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8023237/ https://www.ncbi.nlm.nih.gov/pubmed/33818299 http://dx.doi.org/10.1080/19420862.2021.1890411 |
Ejemplares similares
-
TNB-738, a biparatopic antibody, boosts intracellular NAD+ by inhibiting CD38 ecto-enzyme activity
por: Ugamraj, Harshad S., et al.
Publicado: (2022) -
A T-cell engaging bispecific antibody with a tumor-selective bivalent folate receptor alpha binding arm for the treatment of ovarian cancer
por: Avanzino, Brian C., et al.
Publicado: (2022) -
Sequence-Based Discovery Demonstrates That Fixed Light Chain Human Transgenic Rats Produce a Diverse Repertoire of Antigen-Specific Antibodies
por: Harris, Katherine E., et al.
Publicado: (2018) -
Efficient tumor killing and minimal cytokine release with novel T-cell agonist bispecific antibodies
por: Trinklein, Nathan D., et al.
Publicado: (2019) -
Attenuating CD3 affinity in a PSMAxCD3 bispecific antibody enables killing of prostate tumor cells with reduced cytokine release
por: Dang, Kevin, et al.
Publicado: (2021)