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The Impact of Migration on the Gut Metagenome of South Asian Canadians

South Asian (SA) Canadian immigrants have a higher risk of developing certain immune-mediated inflammatory diseases compared to non-migrant SAs. We sought to investigate the effect of migration on the gut metagenome and to identify microbiological associations between migration and conditions that m...

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Autores principales: Copeland, Julia K., Chao, Gary, Vanderhout, Shelley, Acton, Erica, Wang, Pauline W., Benchimol, Eric I., El-Sohemy, Ahmed, Croitoru, Ken, Gommerman, Jennifer L., Guttman, David S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8023248/
https://www.ncbi.nlm.nih.gov/pubmed/33794735
http://dx.doi.org/10.1080/19490976.2021.1902705
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author Copeland, Julia K.
Chao, Gary
Vanderhout, Shelley
Acton, Erica
Wang, Pauline W.
Benchimol, Eric I.
El-Sohemy, Ahmed
Croitoru, Ken
Gommerman, Jennifer L.
Guttman, David S.
author_facet Copeland, Julia K.
Chao, Gary
Vanderhout, Shelley
Acton, Erica
Wang, Pauline W.
Benchimol, Eric I.
El-Sohemy, Ahmed
Croitoru, Ken
Gommerman, Jennifer L.
Guttman, David S.
author_sort Copeland, Julia K.
collection PubMed
description South Asian (SA) Canadian immigrants have a higher risk of developing certain immune-mediated inflammatory diseases compared to non-migrant SAs. We sought to investigate the effect of migration on the gut metagenome and to identify microbiological associations between migration and conditions that may influence the development of immune-mediated inflammatory diseases. Metagenomic analysis of 58 first-generation (GEN1) SA immigrants and 38 unrelated Canadian born children-of-immigrants (GEN2) determined that the time lived in Canada was associated with continued changes in gut microbial communities. Migration of GEN1 to Canada early in life results in a gut community with similarities to GEN2 SA Canadians and non-SA North Americans. Conversely, GEN1 immigrants who arrived recently to Canada exhibited pronounced differences from GEN2, while displaying microbial similarities to a non-migrating SA cohort. Multivariate analysis identified that community composition was primarily influenced by high abundance taxa. Prevotella copri dominated in GEN1 and non-migrant SAs. Clostridia and functionally related Bacteroidia spp. replaced P. copri dominance over generations in Canada. Mutually exclusive Dialister species occurred at differing relative abundances over time and generations in Canada. This shift in species composition is accompanied by a change in genes associated with carbohydrate utilization and short-chain fatty acid production. Total energy derived from carbohydrates compared to protein consumption was significantly higher for GEN1 recent immigrants, which may influence the functional requirements of the gut community. This study demonstrates the associations between migration and the gut microbiome, which may be further associated with the altered risk of immune-mediated inflammatory diseases observed for SA Canadians.
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spelling pubmed-80232482021-04-15 The Impact of Migration on the Gut Metagenome of South Asian Canadians Copeland, Julia K. Chao, Gary Vanderhout, Shelley Acton, Erica Wang, Pauline W. Benchimol, Eric I. El-Sohemy, Ahmed Croitoru, Ken Gommerman, Jennifer L. Guttman, David S. Gut Microbes Research Paper South Asian (SA) Canadian immigrants have a higher risk of developing certain immune-mediated inflammatory diseases compared to non-migrant SAs. We sought to investigate the effect of migration on the gut metagenome and to identify microbiological associations between migration and conditions that may influence the development of immune-mediated inflammatory diseases. Metagenomic analysis of 58 first-generation (GEN1) SA immigrants and 38 unrelated Canadian born children-of-immigrants (GEN2) determined that the time lived in Canada was associated with continued changes in gut microbial communities. Migration of GEN1 to Canada early in life results in a gut community with similarities to GEN2 SA Canadians and non-SA North Americans. Conversely, GEN1 immigrants who arrived recently to Canada exhibited pronounced differences from GEN2, while displaying microbial similarities to a non-migrating SA cohort. Multivariate analysis identified that community composition was primarily influenced by high abundance taxa. Prevotella copri dominated in GEN1 and non-migrant SAs. Clostridia and functionally related Bacteroidia spp. replaced P. copri dominance over generations in Canada. Mutually exclusive Dialister species occurred at differing relative abundances over time and generations in Canada. This shift in species composition is accompanied by a change in genes associated with carbohydrate utilization and short-chain fatty acid production. Total energy derived from carbohydrates compared to protein consumption was significantly higher for GEN1 recent immigrants, which may influence the functional requirements of the gut community. This study demonstrates the associations between migration and the gut microbiome, which may be further associated with the altered risk of immune-mediated inflammatory diseases observed for SA Canadians. Taylor & Francis 2021-04-02 /pmc/articles/PMC8023248/ /pubmed/33794735 http://dx.doi.org/10.1080/19490976.2021.1902705 Text en © 2021 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Copeland, Julia K.
Chao, Gary
Vanderhout, Shelley
Acton, Erica
Wang, Pauline W.
Benchimol, Eric I.
El-Sohemy, Ahmed
Croitoru, Ken
Gommerman, Jennifer L.
Guttman, David S.
The Impact of Migration on the Gut Metagenome of South Asian Canadians
title The Impact of Migration on the Gut Metagenome of South Asian Canadians
title_full The Impact of Migration on the Gut Metagenome of South Asian Canadians
title_fullStr The Impact of Migration on the Gut Metagenome of South Asian Canadians
title_full_unstemmed The Impact of Migration on the Gut Metagenome of South Asian Canadians
title_short The Impact of Migration on the Gut Metagenome of South Asian Canadians
title_sort impact of migration on the gut metagenome of south asian canadians
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8023248/
https://www.ncbi.nlm.nih.gov/pubmed/33794735
http://dx.doi.org/10.1080/19490976.2021.1902705
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