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Plasma cell dynamics in the bone marrow niche
Using intravital imaging, we report that bone marrow (BM) plasma cells (PCs) are motile. BM PCs exhibit a unique migration pattern, characterized by intermittent periods of high motility and longer stretches of confined migration or arrest. BM PCs accumulate into clusters, which have reduced cell mo...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8023250/ https://www.ncbi.nlm.nih.gov/pubmed/33567286 http://dx.doi.org/10.1016/j.celrep.2021.108733 |
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author | Benet, Zachary Jing, Zhixin Fooksman, David R. |
author_facet | Benet, Zachary Jing, Zhixin Fooksman, David R. |
author_sort | Benet, Zachary |
collection | PubMed |
description | Using intravital imaging, we report that bone marrow (BM) plasma cells (PCs) are motile. BM PCs exhibit a unique migration pattern, characterized by intermittent periods of high motility and longer stretches of confined migration or arrest. BM PCs accumulate into clusters, which have reduced cell motility. APRIL promotes cluster formation and overall PC motility in the BM. Although CXCL12 and its receptor, CXCR4, promote PC motility in the BM, VLA4 activity promotes arrest. However, blocking either pathway promotes PC egress from the BM. Under steady-state conditions, BM PCs recirculate to other bones and spleen. In older mice, overall PC motility and recirculation increase, and this is correlated with increased CXCR4 expression, which depends on PC age or maturation rather than mouse age. Altogether, these results suggest that changes in PC motility and CXCR4 expression are linked with survival of long-lived PCs in the BM. |
format | Online Article Text |
id | pubmed-8023250 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
record_format | MEDLINE/PubMed |
spelling | pubmed-80232502021-04-06 Plasma cell dynamics in the bone marrow niche Benet, Zachary Jing, Zhixin Fooksman, David R. Cell Rep Article Using intravital imaging, we report that bone marrow (BM) plasma cells (PCs) are motile. BM PCs exhibit a unique migration pattern, characterized by intermittent periods of high motility and longer stretches of confined migration or arrest. BM PCs accumulate into clusters, which have reduced cell motility. APRIL promotes cluster formation and overall PC motility in the BM. Although CXCL12 and its receptor, CXCR4, promote PC motility in the BM, VLA4 activity promotes arrest. However, blocking either pathway promotes PC egress from the BM. Under steady-state conditions, BM PCs recirculate to other bones and spleen. In older mice, overall PC motility and recirculation increase, and this is correlated with increased CXCR4 expression, which depends on PC age or maturation rather than mouse age. Altogether, these results suggest that changes in PC motility and CXCR4 expression are linked with survival of long-lived PCs in the BM. 2021-02-09 /pmc/articles/PMC8023250/ /pubmed/33567286 http://dx.doi.org/10.1016/j.celrep.2021.108733 Text en This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Benet, Zachary Jing, Zhixin Fooksman, David R. Plasma cell dynamics in the bone marrow niche |
title | Plasma cell dynamics in the bone marrow niche |
title_full | Plasma cell dynamics in the bone marrow niche |
title_fullStr | Plasma cell dynamics in the bone marrow niche |
title_full_unstemmed | Plasma cell dynamics in the bone marrow niche |
title_short | Plasma cell dynamics in the bone marrow niche |
title_sort | plasma cell dynamics in the bone marrow niche |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8023250/ https://www.ncbi.nlm.nih.gov/pubmed/33567286 http://dx.doi.org/10.1016/j.celrep.2021.108733 |
work_keys_str_mv | AT benetzachary plasmacelldynamicsinthebonemarrowniche AT jingzhixin plasmacelldynamicsinthebonemarrowniche AT fooksmandavidr plasmacelldynamicsinthebonemarrowniche |