Cargando…

Plasma cell dynamics in the bone marrow niche

Using intravital imaging, we report that bone marrow (BM) plasma cells (PCs) are motile. BM PCs exhibit a unique migration pattern, characterized by intermittent periods of high motility and longer stretches of confined migration or arrest. BM PCs accumulate into clusters, which have reduced cell mo...

Descripción completa

Detalles Bibliográficos
Autores principales: Benet, Zachary, Jing, Zhixin, Fooksman, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8023250/
https://www.ncbi.nlm.nih.gov/pubmed/33567286
http://dx.doi.org/10.1016/j.celrep.2021.108733
_version_ 1783675093899018240
author Benet, Zachary
Jing, Zhixin
Fooksman, David R.
author_facet Benet, Zachary
Jing, Zhixin
Fooksman, David R.
author_sort Benet, Zachary
collection PubMed
description Using intravital imaging, we report that bone marrow (BM) plasma cells (PCs) are motile. BM PCs exhibit a unique migration pattern, characterized by intermittent periods of high motility and longer stretches of confined migration or arrest. BM PCs accumulate into clusters, which have reduced cell motility. APRIL promotes cluster formation and overall PC motility in the BM. Although CXCL12 and its receptor, CXCR4, promote PC motility in the BM, VLA4 activity promotes arrest. However, blocking either pathway promotes PC egress from the BM. Under steady-state conditions, BM PCs recirculate to other bones and spleen. In older mice, overall PC motility and recirculation increase, and this is correlated with increased CXCR4 expression, which depends on PC age or maturation rather than mouse age. Altogether, these results suggest that changes in PC motility and CXCR4 expression are linked with survival of long-lived PCs in the BM.
format Online
Article
Text
id pubmed-8023250
institution National Center for Biotechnology Information
language English
publishDate 2021
record_format MEDLINE/PubMed
spelling pubmed-80232502021-04-06 Plasma cell dynamics in the bone marrow niche Benet, Zachary Jing, Zhixin Fooksman, David R. Cell Rep Article Using intravital imaging, we report that bone marrow (BM) plasma cells (PCs) are motile. BM PCs exhibit a unique migration pattern, characterized by intermittent periods of high motility and longer stretches of confined migration or arrest. BM PCs accumulate into clusters, which have reduced cell motility. APRIL promotes cluster formation and overall PC motility in the BM. Although CXCL12 and its receptor, CXCR4, promote PC motility in the BM, VLA4 activity promotes arrest. However, blocking either pathway promotes PC egress from the BM. Under steady-state conditions, BM PCs recirculate to other bones and spleen. In older mice, overall PC motility and recirculation increase, and this is correlated with increased CXCR4 expression, which depends on PC age or maturation rather than mouse age. Altogether, these results suggest that changes in PC motility and CXCR4 expression are linked with survival of long-lived PCs in the BM. 2021-02-09 /pmc/articles/PMC8023250/ /pubmed/33567286 http://dx.doi.org/10.1016/j.celrep.2021.108733 Text en This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Benet, Zachary
Jing, Zhixin
Fooksman, David R.
Plasma cell dynamics in the bone marrow niche
title Plasma cell dynamics in the bone marrow niche
title_full Plasma cell dynamics in the bone marrow niche
title_fullStr Plasma cell dynamics in the bone marrow niche
title_full_unstemmed Plasma cell dynamics in the bone marrow niche
title_short Plasma cell dynamics in the bone marrow niche
title_sort plasma cell dynamics in the bone marrow niche
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8023250/
https://www.ncbi.nlm.nih.gov/pubmed/33567286
http://dx.doi.org/10.1016/j.celrep.2021.108733
work_keys_str_mv AT benetzachary plasmacelldynamicsinthebonemarrowniche
AT jingzhixin plasmacelldynamicsinthebonemarrowniche
AT fooksmandavidr plasmacelldynamicsinthebonemarrowniche