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The Cross-Talk Between Atopic Dermatitis and Diabetes Mellitus: A Meta-Analysis

Introduction: Atopic dermatitis (AD) is associated with various systemic diseases. However, its association with diabetes mellitus (DM) was discussed controversially. Few researchers reviewed the association of these two common morbid disorders. This meta-analysis aimed to assess the relationship be...

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Autores principales: Mirghani, Hyder O, Alhazmi, Khalid, Alghamdi, Salah, Alraddadi, Mohammed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8023342/
https://www.ncbi.nlm.nih.gov/pubmed/33842127
http://dx.doi.org/10.7759/cureus.13750
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author Mirghani, Hyder O
Alhazmi, Khalid
Alghamdi, Salah
Alraddadi, Mohammed
author_facet Mirghani, Hyder O
Alhazmi, Khalid
Alghamdi, Salah
Alraddadi, Mohammed
author_sort Mirghani, Hyder O
collection PubMed
description Introduction: Atopic dermatitis (AD) is associated with various systemic diseases. However, its association with diabetes mellitus (DM) was discussed controversially. Few researchers reviewed the association of these two common morbid disorders. This meta-analysis aimed to assess the relationship between AD and DM. Methods: We systematically searched PubMed including Epub and ahead of print (198 articles identified) and Cochrane (13 articles) databases. The searching engine was set to include case-control, prospective and retrospective cohorts, and cross-sectional studies from the first published up to February 12, 2021. Two hundred and eleven were identified, eighteen full texts were screened; of them, six were included in the final meta-analysis. The keywords used were AD, diabetes mellitus, type 1 diabetes, and type 2 diabetes. A datasheet was used to record the author's name, year of publication, country and type of the studies, number of events, and total number in the two arms (patients and controls). Results: Out of the 211 references identified, six studies were pooled to test the association between diabetes mellitus and AD. The studies showed that AD is lower among patients with DM, odds ratio, 0.69, 95% CI, and 0.67-0.72. No heterogeneity was observed (Chi-Square, 4.12, degree of freedom (df.)= 5, and I(2 )= 0%, P-value), 0.53 and P-value for overall effect, <0.001. The included studies were published in Europe (five) and Canada (one study) and included 162,882 patients and 12,164 events, four of the studied articles were case-control studies, one retrospective, and one cross-sectional. Conclusion: AD was lower among patients with DM compared to their counterparts without the disease. Further studies focusing on the genetic and environmental factors linking AD and diabetes are needed.
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spelling pubmed-80233422021-04-08 The Cross-Talk Between Atopic Dermatitis and Diabetes Mellitus: A Meta-Analysis Mirghani, Hyder O Alhazmi, Khalid Alghamdi, Salah Alraddadi, Mohammed Cureus Dermatology Introduction: Atopic dermatitis (AD) is associated with various systemic diseases. However, its association with diabetes mellitus (DM) was discussed controversially. Few researchers reviewed the association of these two common morbid disorders. This meta-analysis aimed to assess the relationship between AD and DM. Methods: We systematically searched PubMed including Epub and ahead of print (198 articles identified) and Cochrane (13 articles) databases. The searching engine was set to include case-control, prospective and retrospective cohorts, and cross-sectional studies from the first published up to February 12, 2021. Two hundred and eleven were identified, eighteen full texts were screened; of them, six were included in the final meta-analysis. The keywords used were AD, diabetes mellitus, type 1 diabetes, and type 2 diabetes. A datasheet was used to record the author's name, year of publication, country and type of the studies, number of events, and total number in the two arms (patients and controls). Results: Out of the 211 references identified, six studies were pooled to test the association between diabetes mellitus and AD. The studies showed that AD is lower among patients with DM, odds ratio, 0.69, 95% CI, and 0.67-0.72. No heterogeneity was observed (Chi-Square, 4.12, degree of freedom (df.)= 5, and I(2 )= 0%, P-value), 0.53 and P-value for overall effect, <0.001. The included studies were published in Europe (five) and Canada (one study) and included 162,882 patients and 12,164 events, four of the studied articles were case-control studies, one retrospective, and one cross-sectional. Conclusion: AD was lower among patients with DM compared to their counterparts without the disease. Further studies focusing on the genetic and environmental factors linking AD and diabetes are needed. Cureus 2021-03-07 /pmc/articles/PMC8023342/ /pubmed/33842127 http://dx.doi.org/10.7759/cureus.13750 Text en Copyright © 2021, Mirghani et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Dermatology
Mirghani, Hyder O
Alhazmi, Khalid
Alghamdi, Salah
Alraddadi, Mohammed
The Cross-Talk Between Atopic Dermatitis and Diabetes Mellitus: A Meta-Analysis
title The Cross-Talk Between Atopic Dermatitis and Diabetes Mellitus: A Meta-Analysis
title_full The Cross-Talk Between Atopic Dermatitis and Diabetes Mellitus: A Meta-Analysis
title_fullStr The Cross-Talk Between Atopic Dermatitis and Diabetes Mellitus: A Meta-Analysis
title_full_unstemmed The Cross-Talk Between Atopic Dermatitis and Diabetes Mellitus: A Meta-Analysis
title_short The Cross-Talk Between Atopic Dermatitis and Diabetes Mellitus: A Meta-Analysis
title_sort cross-talk between atopic dermatitis and diabetes mellitus: a meta-analysis
topic Dermatology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8023342/
https://www.ncbi.nlm.nih.gov/pubmed/33842127
http://dx.doi.org/10.7759/cureus.13750
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