CD169/SIGLEC1 is expressed on circulating monocytes in COVID-19 and expression levels are associated with disease severity

Coronavirus disease 2019 (COVID-19) is caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Type I interferons are important in the defense of viral infections. Recently, neutralizing IgG auto-antibodies against type I interferons were found in patients with severe...

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Detalles Bibliográficos
Autores principales: Doehn, Jan-Moritz, Tabeling, Christoph, Biesen, Robert, Saccomanno, Jacopo, Madlung, Elena, Pappe, Eva, Gabriel, Frieder, Kurth, Florian, Meisel, Christian, Corman, Victor M., Hanitsch, Leif G., Treskatsch, Sascha, Heim, Kathrin, Stegemann, Miriam S., Ruwwe-Glösenkamp, Christoph, Müller-Redetzky, Holger C., Uhrig, Alexander, Somasundaram, Rajan, Spies, Claudia, von Bernuth, Horst, Hofmann, Jörg, Drosten, Christian, Suttorp, Norbert, Witzenrath, Martin, Sander, Leif E., Hübner, Ralf-Harto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8023546/
https://www.ncbi.nlm.nih.gov/pubmed/33825125
http://dx.doi.org/10.1007/s15010-021-01606-9
Descripción
Sumario:Coronavirus disease 2019 (COVID-19) is caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Type I interferons are important in the defense of viral infections. Recently, neutralizing IgG auto-antibodies against type I interferons were found in patients with severe COVID-19 infection. Here, we analyzed expression of CD169/SIGLEC1, a well described downstream molecule in interferon signaling, and found increased monocytic CD169/SIGLEC1 expression levels in patients with mild, acute COVID-19, compared to patients with severe disease. We recommend further clinical studies to evaluate the value of CD169/SIGLEC1 expression in patients with COVID-19 with or without auto-antibodies against type I interferons.

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