CD169/SIGLEC1 is expressed on circulating monocytes in COVID-19 and expression levels are associated with disease severity

Coronavirus disease 2019 (COVID-19) is caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Type I interferons are important in the defense of viral infections. Recently, neutralizing IgG auto-antibodies against type I interferons were found in patients with severe...

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Autores principales: Doehn, Jan-Moritz, Tabeling, Christoph, Biesen, Robert, Saccomanno, Jacopo, Madlung, Elena, Pappe, Eva, Gabriel, Frieder, Kurth, Florian, Meisel, Christian, Corman, Victor M., Hanitsch, Leif G., Treskatsch, Sascha, Heim, Kathrin, Stegemann, Miriam S., Ruwwe-Glösenkamp, Christoph, Müller-Redetzky, Holger C., Uhrig, Alexander, Somasundaram, Rajan, Spies, Claudia, von Bernuth, Horst, Hofmann, Jörg, Drosten, Christian, Suttorp, Norbert, Witzenrath, Martin, Sander, Leif E., Hübner, Ralf-Harto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8023546/
https://www.ncbi.nlm.nih.gov/pubmed/33825125
http://dx.doi.org/10.1007/s15010-021-01606-9
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author Doehn, Jan-Moritz
Tabeling, Christoph
Biesen, Robert
Saccomanno, Jacopo
Madlung, Elena
Pappe, Eva
Gabriel, Frieder
Kurth, Florian
Meisel, Christian
Corman, Victor M.
Hanitsch, Leif G.
Treskatsch, Sascha
Heim, Kathrin
Stegemann, Miriam S.
Ruwwe-Glösenkamp, Christoph
Müller-Redetzky, Holger C.
Uhrig, Alexander
Somasundaram, Rajan
Spies, Claudia
von Bernuth, Horst
Hofmann, Jörg
Drosten, Christian
Suttorp, Norbert
Witzenrath, Martin
Sander, Leif E.
Hübner, Ralf-Harto
author_facet Doehn, Jan-Moritz
Tabeling, Christoph
Biesen, Robert
Saccomanno, Jacopo
Madlung, Elena
Pappe, Eva
Gabriel, Frieder
Kurth, Florian
Meisel, Christian
Corman, Victor M.
Hanitsch, Leif G.
Treskatsch, Sascha
Heim, Kathrin
Stegemann, Miriam S.
Ruwwe-Glösenkamp, Christoph
Müller-Redetzky, Holger C.
Uhrig, Alexander
Somasundaram, Rajan
Spies, Claudia
von Bernuth, Horst
Hofmann, Jörg
Drosten, Christian
Suttorp, Norbert
Witzenrath, Martin
Sander, Leif E.
Hübner, Ralf-Harto
author_sort Doehn, Jan-Moritz
collection PubMed
description Coronavirus disease 2019 (COVID-19) is caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Type I interferons are important in the defense of viral infections. Recently, neutralizing IgG auto-antibodies against type I interferons were found in patients with severe COVID-19 infection. Here, we analyzed expression of CD169/SIGLEC1, a well described downstream molecule in interferon signaling, and found increased monocytic CD169/SIGLEC1 expression levels in patients with mild, acute COVID-19, compared to patients with severe disease. We recommend further clinical studies to evaluate the value of CD169/SIGLEC1 expression in patients with COVID-19 with or without auto-antibodies against type I interferons.
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spelling pubmed-80235462021-04-07 CD169/SIGLEC1 is expressed on circulating monocytes in COVID-19 and expression levels are associated with disease severity Doehn, Jan-Moritz Tabeling, Christoph Biesen, Robert Saccomanno, Jacopo Madlung, Elena Pappe, Eva Gabriel, Frieder Kurth, Florian Meisel, Christian Corman, Victor M. Hanitsch, Leif G. Treskatsch, Sascha Heim, Kathrin Stegemann, Miriam S. Ruwwe-Glösenkamp, Christoph Müller-Redetzky, Holger C. Uhrig, Alexander Somasundaram, Rajan Spies, Claudia von Bernuth, Horst Hofmann, Jörg Drosten, Christian Suttorp, Norbert Witzenrath, Martin Sander, Leif E. Hübner, Ralf-Harto Infection Brief Report Coronavirus disease 2019 (COVID-19) is caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Type I interferons are important in the defense of viral infections. Recently, neutralizing IgG auto-antibodies against type I interferons were found in patients with severe COVID-19 infection. Here, we analyzed expression of CD169/SIGLEC1, a well described downstream molecule in interferon signaling, and found increased monocytic CD169/SIGLEC1 expression levels in patients with mild, acute COVID-19, compared to patients with severe disease. We recommend further clinical studies to evaluate the value of CD169/SIGLEC1 expression in patients with COVID-19 with or without auto-antibodies against type I interferons. Springer Berlin Heidelberg 2021-04-06 2021 /pmc/articles/PMC8023546/ /pubmed/33825125 http://dx.doi.org/10.1007/s15010-021-01606-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Report
Doehn, Jan-Moritz
Tabeling, Christoph
Biesen, Robert
Saccomanno, Jacopo
Madlung, Elena
Pappe, Eva
Gabriel, Frieder
Kurth, Florian
Meisel, Christian
Corman, Victor M.
Hanitsch, Leif G.
Treskatsch, Sascha
Heim, Kathrin
Stegemann, Miriam S.
Ruwwe-Glösenkamp, Christoph
Müller-Redetzky, Holger C.
Uhrig, Alexander
Somasundaram, Rajan
Spies, Claudia
von Bernuth, Horst
Hofmann, Jörg
Drosten, Christian
Suttorp, Norbert
Witzenrath, Martin
Sander, Leif E.
Hübner, Ralf-Harto
CD169/SIGLEC1 is expressed on circulating monocytes in COVID-19 and expression levels are associated with disease severity
title CD169/SIGLEC1 is expressed on circulating monocytes in COVID-19 and expression levels are associated with disease severity
title_full CD169/SIGLEC1 is expressed on circulating monocytes in COVID-19 and expression levels are associated with disease severity
title_fullStr CD169/SIGLEC1 is expressed on circulating monocytes in COVID-19 and expression levels are associated with disease severity
title_full_unstemmed CD169/SIGLEC1 is expressed on circulating monocytes in COVID-19 and expression levels are associated with disease severity
title_short CD169/SIGLEC1 is expressed on circulating monocytes in COVID-19 and expression levels are associated with disease severity
title_sort cd169/siglec1 is expressed on circulating monocytes in covid-19 and expression levels are associated with disease severity
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8023546/
https://www.ncbi.nlm.nih.gov/pubmed/33825125
http://dx.doi.org/10.1007/s15010-021-01606-9
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