The identification of novel inhibitors of human angiotensin-converting enzyme 2 and main protease of Sars-Cov-2: A combination of in silico methods for treatment of COVID-19

The angiotensin-converting enzyme 2 (ACE2) and main protease (MPro), are the putative drug candidates for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this study, we performed 3D-QSAR pharmacophore modeling and screened 1,264,479 ligands gathered from Pubchem and Zinc databas...

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Detalles Bibliográficos
Autores principales: Zarezade, Vahid, Rezaei, Hamzeh, Shakerinezhad, Ghodratollah, Safavi, Arman, Nazeri, Zahra, Veisi, Ali, Azadbakht, Omid, Hatami, Mahdi, Sabaghan, Mohamad, Shajirat, Zeinab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8023563/
https://www.ncbi.nlm.nih.gov/pubmed/33840836
http://dx.doi.org/10.1016/j.molstruc.2021.130409

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