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Efficient In Silico Saturation Mutagenesis of a Member of the Caspase Protease Family

[Image: see text] Rational-design methods have proven to be a valuable toolkit in the field of protein design. Numerical approaches such as free-energy calculations or QM/MM methods are fit to widen the understanding of a protein-sequence space but require large amounts of computational time and pow...

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Detalles Bibliográficos
Autores principales:	Öhlknecht, Christoph, Katz, Sonja, Kröß, Christina, Sprenger, Bernhard, Engele, Petra, Schneider, Rainer, Oostenbrink, Chris
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8023567/ https://www.ncbi.nlm.nih.gov/pubmed/33570387 http://dx.doi.org/10.1021/acs.jcim.0c01216

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