Multiple Applications of a Novel Biarsenical Imaging Probe in Fluorescence and PET Imaging of Melanoma

[Image: see text] A new fluorescent biarsenical peptide labeling probe was synthesized and labeled with the radioactive isotopes (11)C and (18)F. The utility of this probe was demonstrated by installing each of these isotopes into a melanocortin 1 receptor (MC1R) binding peptide, which targets melan...

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Detalles Bibliográficos
Autores principales: Kondrashov, Mikhail, Svensson, Samuel P. S., Ström, Peter, Westermark, Andreas, Jacobson-Ingemyr, Hanna, Takano, Akihiro, Tari, Lenke, Tóth, Miklós, Cai, Minying, Hruby, Victor J., Schou, Magnus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8023571/
https://www.ncbi.nlm.nih.gov/pubmed/33576604
http://dx.doi.org/10.1021/acs.bioconjchem.0c00671
Descripción
Sumario:[Image: see text] A new fluorescent biarsenical peptide labeling probe was synthesized and labeled with the radioactive isotopes (11)C and (18)F. The utility of this probe was demonstrated by installing each of these isotopes into a melanocortin 1 receptor (MC1R) binding peptide, which targets melanoma tumors. Its applicability was further showcased by subsequent in vitro imaging in cells as well as in vivo imaging in melanoma xenograft mice by fluorescence and positron emission tomography.

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