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Orthosteric and Allosteric Dual Targeting of the Nuclear Receptor RORγt with a Bitopic Ligand

[Image: see text] The RORγt nuclear receptor (NR) is of critical importance for the differentiation and proliferation of T helper 17 (Th17) cells and their production of the pro-inflammatory cytokine IL-17a. Dysregulation of RORγt has been linked to various autoimmune diseases, and small molecule in...

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Detalles Bibliográficos
Autores principales:	Meijer, Femke A., Oerlemans, Guido J.M., Brunsveld, Luc
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8023582/ https://www.ncbi.nlm.nih.gov/pubmed/33596047 http://dx.doi.org/10.1021/acschembio.0c00941

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