pH and ROS sequentially responsive podophyllotoxin prodrug micelles with surface charge-switchable and self-amplification drug release for combating multidrug resistance cancer

Multidrug resistance (MDR) is one of the main reasons for tumor chemotherapy failure. Podophyllotoxin (PPT) has been reported that can suppress MDR cancer cell growth; however, effective delivery of PPT to MDR cancer cells is challenged by cascaded bio-barriers. To effectively deliver PPT to MDR can...

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Detalles Bibliográficos
Autores principales: Li, Chao, Wang, Yifan, Zhang, Shuo, Zhang, Jiaojiao, Wang, Fang, Sun, Yunhao, Huang, Lirong, Bian, Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8023596/
https://www.ncbi.nlm.nih.gov/pubmed/33818237
http://dx.doi.org/10.1080/10717544.2021.1905750

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