Unintentional ingestion of a high dose of acenocoumarol in a young child

Acute intoxication with a vitamin K antagonist may cause serious coagulopathy. We report the accidental ingestion of a high dose of acenocoumarol in a young child. Two intravenous administrations of 5 mg of vitamin K, in combination with fast and repeated administration of activated charcoal and sod...

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Autores principales: Brands, Martijn R, Sytema, Jelmer, van Hulst, Marinus, Kamps, Arvid WA
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8023619/
https://www.ncbi.nlm.nih.gov/pubmed/33795273
http://dx.doi.org/10.1136/bcr-2020-240365
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author Brands, Martijn R
Sytema, Jelmer
van Hulst, Marinus
Kamps, Arvid WA
author_facet Brands, Martijn R
Sytema, Jelmer
van Hulst, Marinus
Kamps, Arvid WA
author_sort Brands, Martijn R
collection PubMed
description Acute intoxication with a vitamin K antagonist may cause serious coagulopathy. We report the accidental ingestion of a high dose of acenocoumarol in a young child. Two intravenous administrations of 5 mg of vitamin K, in combination with fast and repeated administration of activated charcoal and sodium sulfate, were sufficient to prevent coagulopathy and related symptoms, despite a confirmed elevated blood acenocoumarol concentration (260 µg/L).
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spelling pubmed-80236192021-04-21 Unintentional ingestion of a high dose of acenocoumarol in a young child Brands, Martijn R Sytema, Jelmer van Hulst, Marinus Kamps, Arvid WA BMJ Case Rep Case Report Acute intoxication with a vitamin K antagonist may cause serious coagulopathy. We report the accidental ingestion of a high dose of acenocoumarol in a young child. Two intravenous administrations of 5 mg of vitamin K, in combination with fast and repeated administration of activated charcoal and sodium sulfate, were sufficient to prevent coagulopathy and related symptoms, despite a confirmed elevated blood acenocoumarol concentration (260 µg/L). BMJ Publishing Group 2021-04-01 /pmc/articles/PMC8023619/ /pubmed/33795273 http://dx.doi.org/10.1136/bcr-2020-240365 Text en © BMJ Publishing Group Limited 2021. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/ https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
spellingShingle Case Report
Brands, Martijn R
Sytema, Jelmer
van Hulst, Marinus
Kamps, Arvid WA
Unintentional ingestion of a high dose of acenocoumarol in a young child
title Unintentional ingestion of a high dose of acenocoumarol in a young child
title_full Unintentional ingestion of a high dose of acenocoumarol in a young child
title_fullStr Unintentional ingestion of a high dose of acenocoumarol in a young child
title_full_unstemmed Unintentional ingestion of a high dose of acenocoumarol in a young child
title_short Unintentional ingestion of a high dose of acenocoumarol in a young child
title_sort unintentional ingestion of a high dose of acenocoumarol in a young child
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8023619/
https://www.ncbi.nlm.nih.gov/pubmed/33795273
http://dx.doi.org/10.1136/bcr-2020-240365
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AT vanhulstmarinus unintentionalingestionofahighdoseofacenocoumarolinayoungchild
AT kampsarvidwa unintentionalingestionofahighdoseofacenocoumarolinayoungchild

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