Experimental Confirmation of a Topological Isomer of the Ubiquitous Au(25)(SR)(18) Cluster in the Gas Phase

[Image: see text] High-resolution electrospray ionization ion mobility mass spectrometry has revealed a gas-phase isomer of the ubiquitous, extremely well-studied Au(25)(SR)(18) cluster both in anionic and cationic form. The relative abundance of the isomeric structures can be controlled by in-source activation. The measured collision cross section of the new isomer agrees extremely well with a recent theoretical prediction ( M. F. Matus; et al. Chem. Commun.2020, 56, 8087) corresponding to a Au(25)(SR)(18)(–) isomer that is energetically close and topologically connected to the known ground-state structure via a simple rotation of the gold core without breaking any Au–S bonds. The results imply that the structural dynamics leading to isomerization of thiolate-protected gold clusters may play an important role in their gas-phase reactions and that isomerization could be controlled by external stimuli.