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Synonymous variants that disrupt messenger RNA structure are significantly constrained in the human population
BACKGROUND: The role of synonymous single-nucleotide variants in human health and disease is poorly understood, yet evidence suggests that this class of “silent” genetic variation plays multiple regulatory roles in both transcription and translation. One mechanism by which synonymous codons direct a...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8023685/ https://www.ncbi.nlm.nih.gov/pubmed/33822938 http://dx.doi.org/10.1093/gigascience/giab023 |