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Obesity and its impact on COVID-19

The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) pandemic has proven a challenge to healthcare systems since its first appearance in late 2019. The global spread and devastating effects of coronavirus disease 2019 (COVID-19) on patients have resulted in countless studies on risk fact...

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Autores principales: de Leeuw, Angélica J. M., Oude Luttikhuis, Maureen A. M., Wellen, Annemarijn C., Müller, Christine, Calkhoven, Cornelis F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8023779/
https://www.ncbi.nlm.nih.gov/pubmed/33824998
http://dx.doi.org/10.1007/s00109-021-02072-4
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author de Leeuw, Angélica J. M.
Oude Luttikhuis, Maureen A. M.
Wellen, Annemarijn C.
Müller, Christine
Calkhoven, Cornelis F.
author_facet de Leeuw, Angélica J. M.
Oude Luttikhuis, Maureen A. M.
Wellen, Annemarijn C.
Müller, Christine
Calkhoven, Cornelis F.
author_sort de Leeuw, Angélica J. M.
collection PubMed
description The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) pandemic has proven a challenge to healthcare systems since its first appearance in late 2019. The global spread and devastating effects of coronavirus disease 2019 (COVID-19) on patients have resulted in countless studies on risk factors and disease progression. Overweight and obesity emerged as one of the major risk factors for developing severe COVID-19. Here we review the biology of coronavirus infections in relation to obesity. In particular, we review literature about the impact of adiposity-related systemic inflammation on the COVID-19 disease severity, involving cytokine, chemokine, leptin, and growth hormone signaling, and we discuss the involvement of hyperactivation of the renin-angiotensin-aldosterone system (RAAS). Due to the sheer number of publications on COVID-19, we cannot be completed, and therefore, we apologize for all the publications that we do not cite.
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spelling pubmed-80237792021-04-07 Obesity and its impact on COVID-19 de Leeuw, Angélica J. M. Oude Luttikhuis, Maureen A. M. Wellen, Annemarijn C. Müller, Christine Calkhoven, Cornelis F. J Mol Med (Berl) Review The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) pandemic has proven a challenge to healthcare systems since its first appearance in late 2019. The global spread and devastating effects of coronavirus disease 2019 (COVID-19) on patients have resulted in countless studies on risk factors and disease progression. Overweight and obesity emerged as one of the major risk factors for developing severe COVID-19. Here we review the biology of coronavirus infections in relation to obesity. In particular, we review literature about the impact of adiposity-related systemic inflammation on the COVID-19 disease severity, involving cytokine, chemokine, leptin, and growth hormone signaling, and we discuss the involvement of hyperactivation of the renin-angiotensin-aldosterone system (RAAS). Due to the sheer number of publications on COVID-19, we cannot be completed, and therefore, we apologize for all the publications that we do not cite. Springer Berlin Heidelberg 2021-04-06 2021 /pmc/articles/PMC8023779/ /pubmed/33824998 http://dx.doi.org/10.1007/s00109-021-02072-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
de Leeuw, Angélica J. M.
Oude Luttikhuis, Maureen A. M.
Wellen, Annemarijn C.
Müller, Christine
Calkhoven, Cornelis F.
Obesity and its impact on COVID-19
title Obesity and its impact on COVID-19
title_full Obesity and its impact on COVID-19
title_fullStr Obesity and its impact on COVID-19
title_full_unstemmed Obesity and its impact on COVID-19
title_short Obesity and its impact on COVID-19
title_sort obesity and its impact on covid-19
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8023779/
https://www.ncbi.nlm.nih.gov/pubmed/33824998
http://dx.doi.org/10.1007/s00109-021-02072-4
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