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Tyrosine Kinase 2 Signalling Drives Pathogenic T cells in Colitis

BACKGROUND AND AIMS: Tyrosine kinase 2 [TYK2] is required for the signalling of key cytokines in the pathogenesis of inflammatory bowel disease [IBD]. We assessed the efficacy of a novel selective TYK2 inhibitor [TYK2i] in experimental colitis, using pharmacological and genetic tools. METHODS: At on...

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Detalles Bibliográficos
Autores principales:	De Vries, Leonie C S, Ghiboub, Mohammed, van Hamersveld, Patricia H P, Welting, Olaf, Verseijden, Caroline, Bell, Matthew J, Rioja, Inmaculada, Prinjha, Rabinder K, Koelink, Pim J, Strobl, Birgit, Müller, Mathias, D’Haens, Geert R, Wildenberg, Manon E, De Jonge, Wouter J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8023831/ https://www.ncbi.nlm.nih.gov/pubmed/33005945 http://dx.doi.org/10.1093/ecco-jcc/jjaa199

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