Cargando…

Differing Age-Specific Cervical Cancer Incidence Between Different Types of Human Papillomavirus: Implications for Predicting the Impact of Elimination Programs

The elimination of cervical cancer rests on high efficacy of human papillomavirus (HPV) vaccines. The HPV type distribution among cases of invasive cervical cancer (ICC) is used to make predictions about the impact of eliminating different types of HPV, but accumulating evidence of differences in ag...

Descripción completa

Detalles Bibliográficos
Autores principales: Vänskä, Simopekka, Luostarinen, Tapio, Lagheden, Camilla, Eklund, Carina, Kleppe, Sara Nordqvist, Andrae, Bengt, Sparén, Pär, Sundström, Karin, Lehtinen, Matti, Dillner, Joakim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024050/
https://www.ncbi.nlm.nih.gov/pubmed/32639531
http://dx.doi.org/10.1093/aje/kwaa121
_version_ 1783675230670028800
author Vänskä, Simopekka
Luostarinen, Tapio
Lagheden, Camilla
Eklund, Carina
Kleppe, Sara Nordqvist
Andrae, Bengt
Sparén, Pär
Sundström, Karin
Lehtinen, Matti
Dillner, Joakim
author_facet Vänskä, Simopekka
Luostarinen, Tapio
Lagheden, Camilla
Eklund, Carina
Kleppe, Sara Nordqvist
Andrae, Bengt
Sparén, Pär
Sundström, Karin
Lehtinen, Matti
Dillner, Joakim
author_sort Vänskä, Simopekka
collection PubMed
description The elimination of cervical cancer rests on high efficacy of human papillomavirus (HPV) vaccines. The HPV type distribution among cases of invasive cervical cancer (ICC) is used to make predictions about the impact of eliminating different types of HPV, but accumulating evidence of differences in age-specific cancer incidence by HPV type exists. We used one of the largest population-based series of HPV genotyping of ICCs (n = 2,850; Sweden, 2002–2011) to estimate age-specific ICC incidence by HPV type and obtain estimates of the cancer-protective impact of the removal of different HPV types. In the base case, the age-specific ICC incidence had 2 peaks, and the standardized lifetime risk (SLTR, the lifetime number of cases per birth cohort of 100,000 females) for HPV-positive ICC was 651 per 100,000 female births. In the absence of vaccine types HPV 16 and HPV 18, the SLTR for ICC was reduced to 157 per 100,000 female births (24% of HPV-positive SLTR). Elimination of all 9 types that can currently be vaccinated against reduced the remaining SLTR to 47 per 100,000 female births (7%), the remaining ICC incidence only slowly increasing with age. In conclusion, after elimination of vaccine-protected HPV types, very few cases of ICC will be left, especially among fertile, reproductive-age women.
format Online
Article
Text
id pubmed-8024050
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-80240502021-04-13 Differing Age-Specific Cervical Cancer Incidence Between Different Types of Human Papillomavirus: Implications for Predicting the Impact of Elimination Programs Vänskä, Simopekka Luostarinen, Tapio Lagheden, Camilla Eklund, Carina Kleppe, Sara Nordqvist Andrae, Bengt Sparén, Pär Sundström, Karin Lehtinen, Matti Dillner, Joakim Am J Epidemiol Original Contribution The elimination of cervical cancer rests on high efficacy of human papillomavirus (HPV) vaccines. The HPV type distribution among cases of invasive cervical cancer (ICC) is used to make predictions about the impact of eliminating different types of HPV, but accumulating evidence of differences in age-specific cancer incidence by HPV type exists. We used one of the largest population-based series of HPV genotyping of ICCs (n = 2,850; Sweden, 2002–2011) to estimate age-specific ICC incidence by HPV type and obtain estimates of the cancer-protective impact of the removal of different HPV types. In the base case, the age-specific ICC incidence had 2 peaks, and the standardized lifetime risk (SLTR, the lifetime number of cases per birth cohort of 100,000 females) for HPV-positive ICC was 651 per 100,000 female births. In the absence of vaccine types HPV 16 and HPV 18, the SLTR for ICC was reduced to 157 per 100,000 female births (24% of HPV-positive SLTR). Elimination of all 9 types that can currently be vaccinated against reduced the remaining SLTR to 47 per 100,000 female births (7%), the remaining ICC incidence only slowly increasing with age. In conclusion, after elimination of vaccine-protected HPV types, very few cases of ICC will be left, especially among fertile, reproductive-age women. Oxford University Press 2020-07-08 /pmc/articles/PMC8024050/ /pubmed/32639531 http://dx.doi.org/10.1093/aje/kwaa121 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Original Contribution
Vänskä, Simopekka
Luostarinen, Tapio
Lagheden, Camilla
Eklund, Carina
Kleppe, Sara Nordqvist
Andrae, Bengt
Sparén, Pär
Sundström, Karin
Lehtinen, Matti
Dillner, Joakim
Differing Age-Specific Cervical Cancer Incidence Between Different Types of Human Papillomavirus: Implications for Predicting the Impact of Elimination Programs
title Differing Age-Specific Cervical Cancer Incidence Between Different Types of Human Papillomavirus: Implications for Predicting the Impact of Elimination Programs
title_full Differing Age-Specific Cervical Cancer Incidence Between Different Types of Human Papillomavirus: Implications for Predicting the Impact of Elimination Programs
title_fullStr Differing Age-Specific Cervical Cancer Incidence Between Different Types of Human Papillomavirus: Implications for Predicting the Impact of Elimination Programs
title_full_unstemmed Differing Age-Specific Cervical Cancer Incidence Between Different Types of Human Papillomavirus: Implications for Predicting the Impact of Elimination Programs
title_short Differing Age-Specific Cervical Cancer Incidence Between Different Types of Human Papillomavirus: Implications for Predicting the Impact of Elimination Programs
title_sort differing age-specific cervical cancer incidence between different types of human papillomavirus: implications for predicting the impact of elimination programs
topic Original Contribution
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024050/
https://www.ncbi.nlm.nih.gov/pubmed/32639531
http://dx.doi.org/10.1093/aje/kwaa121
work_keys_str_mv AT vanskasimopekka differingagespecificcervicalcancerincidencebetweendifferenttypesofhumanpapillomavirusimplicationsforpredictingtheimpactofeliminationprograms
AT luostarinentapio differingagespecificcervicalcancerincidencebetweendifferenttypesofhumanpapillomavirusimplicationsforpredictingtheimpactofeliminationprograms
AT laghedencamilla differingagespecificcervicalcancerincidencebetweendifferenttypesofhumanpapillomavirusimplicationsforpredictingtheimpactofeliminationprograms
AT eklundcarina differingagespecificcervicalcancerincidencebetweendifferenttypesofhumanpapillomavirusimplicationsforpredictingtheimpactofeliminationprograms
AT kleppesaranordqvist differingagespecificcervicalcancerincidencebetweendifferenttypesofhumanpapillomavirusimplicationsforpredictingtheimpactofeliminationprograms
AT andraebengt differingagespecificcervicalcancerincidencebetweendifferenttypesofhumanpapillomavirusimplicationsforpredictingtheimpactofeliminationprograms
AT sparenpar differingagespecificcervicalcancerincidencebetweendifferenttypesofhumanpapillomavirusimplicationsforpredictingtheimpactofeliminationprograms
AT sundstromkarin differingagespecificcervicalcancerincidencebetweendifferenttypesofhumanpapillomavirusimplicationsforpredictingtheimpactofeliminationprograms
AT lehtinenmatti differingagespecificcervicalcancerincidencebetweendifferenttypesofhumanpapillomavirusimplicationsforpredictingtheimpactofeliminationprograms
AT dillnerjoakim differingagespecificcervicalcancerincidencebetweendifferenttypesofhumanpapillomavirusimplicationsforpredictingtheimpactofeliminationprograms