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New Developments and Insights in the Improvement of Mycobacterium tuberculosis Vaccines and Diagnostics Within the End TB Strategy

PURPOSE OF REVIEW: The alignment of sustainable development goals (SDGs) with the End Tuberculosis (TB) strategy provides an integrated roadmap to implement key approaches towards TB elimination. This review summarizes current social challenges for TB control, and yet, recent developments in TB diag...

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Autores principales: García, Juan Ignacio, Allué-Guardia, Anna, Tampi, Radhika P., Restrepo, Blanca I., Torrelles, Jordi B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024105/
https://www.ncbi.nlm.nih.gov/pubmed/33842192
http://dx.doi.org/10.1007/s40471-021-00269-2
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author García, Juan Ignacio
Allué-Guardia, Anna
Tampi, Radhika P.
Restrepo, Blanca I.
Torrelles, Jordi B.
author_facet García, Juan Ignacio
Allué-Guardia, Anna
Tampi, Radhika P.
Restrepo, Blanca I.
Torrelles, Jordi B.
author_sort García, Juan Ignacio
collection PubMed
description PURPOSE OF REVIEW: The alignment of sustainable development goals (SDGs) with the End Tuberculosis (TB) strategy provides an integrated roadmap to implement key approaches towards TB elimination. This review summarizes current social challenges for TB control, and yet, recent developments in TB diagnosis and vaccines in the context of the End TB strategy and SDGs to transform global health. RECENT FINDINGS: Advances in non-sputum based TB biomarkers and whole genome sequencing technologies could revolutionize TB diagnostics. Moreover, synergistic novel technologies such as mRNA vaccination, nanovaccines and promising TB vaccine models are key promising developments for TB prevention and control. SUMMARY: The End TB strategy depends on novel developments in point-of-care TB diagnostics and effective vaccines. However, despite outstanding technological developments in these fields, TB elimination will be unlikely achieved if TB social determinants are not fully addressed. Indeed, the End TB strategy and SDGs emphasize the importance of implementing sustainable universal health coverage and social protection.
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spelling pubmed-80241052021-04-07 New Developments and Insights in the Improvement of Mycobacterium tuberculosis Vaccines and Diagnostics Within the End TB Strategy García, Juan Ignacio Allué-Guardia, Anna Tampi, Radhika P. Restrepo, Blanca I. Torrelles, Jordi B. Curr Epidemiol Rep Infectious Disease Epidemiology (M Yotebieng, Section Editor) PURPOSE OF REVIEW: The alignment of sustainable development goals (SDGs) with the End Tuberculosis (TB) strategy provides an integrated roadmap to implement key approaches towards TB elimination. This review summarizes current social challenges for TB control, and yet, recent developments in TB diagnosis and vaccines in the context of the End TB strategy and SDGs to transform global health. RECENT FINDINGS: Advances in non-sputum based TB biomarkers and whole genome sequencing technologies could revolutionize TB diagnostics. Moreover, synergistic novel technologies such as mRNA vaccination, nanovaccines and promising TB vaccine models are key promising developments for TB prevention and control. SUMMARY: The End TB strategy depends on novel developments in point-of-care TB diagnostics and effective vaccines. However, despite outstanding technological developments in these fields, TB elimination will be unlikely achieved if TB social determinants are not fully addressed. Indeed, the End TB strategy and SDGs emphasize the importance of implementing sustainable universal health coverage and social protection. Springer International Publishing 2021-04-07 2021 /pmc/articles/PMC8024105/ /pubmed/33842192 http://dx.doi.org/10.1007/s40471-021-00269-2 Text en © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Infectious Disease Epidemiology (M Yotebieng, Section Editor)
García, Juan Ignacio
Allué-Guardia, Anna
Tampi, Radhika P.
Restrepo, Blanca I.
Torrelles, Jordi B.
New Developments and Insights in the Improvement of Mycobacterium tuberculosis Vaccines and Diagnostics Within the End TB Strategy
title New Developments and Insights in the Improvement of Mycobacterium tuberculosis Vaccines and Diagnostics Within the End TB Strategy
title_full New Developments and Insights in the Improvement of Mycobacterium tuberculosis Vaccines and Diagnostics Within the End TB Strategy
title_fullStr New Developments and Insights in the Improvement of Mycobacterium tuberculosis Vaccines and Diagnostics Within the End TB Strategy
title_full_unstemmed New Developments and Insights in the Improvement of Mycobacterium tuberculosis Vaccines and Diagnostics Within the End TB Strategy
title_short New Developments and Insights in the Improvement of Mycobacterium tuberculosis Vaccines and Diagnostics Within the End TB Strategy
title_sort new developments and insights in the improvement of mycobacterium tuberculosis vaccines and diagnostics within the end tb strategy
topic Infectious Disease Epidemiology (M Yotebieng, Section Editor)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024105/
https://www.ncbi.nlm.nih.gov/pubmed/33842192
http://dx.doi.org/10.1007/s40471-021-00269-2
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