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Systematic review of literature and analysis of big data from the National Health Insurance System on primary immunodeficiencies in Korea

There are very scant data on the epidemiology of primary immunodeficiency diseases (PIDs) in Korea. Here we attempted to estimate the PID epidemiology and disease burden in Korea. A systematic review was performed of studies retrieved from the PubMed, KoreaMed, and Google Scholar databases. Studies...

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Autores principales: Son, Sohee, Kang, Ji-Man, Hahn, Younsoo, Ahn, Kangmo, Kim, Yae-Jean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Pediatric Society 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024117/
https://www.ncbi.nlm.nih.gov/pubmed/32683811
http://dx.doi.org/10.3345/cep.2019.01347
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author Son, Sohee
Kang, Ji-Man
Hahn, Younsoo
Ahn, Kangmo
Kim, Yae-Jean
author_facet Son, Sohee
Kang, Ji-Man
Hahn, Younsoo
Ahn, Kangmo
Kim, Yae-Jean
author_sort Son, Sohee
collection PubMed
description There are very scant data on the epidemiology of primary immunodeficiency diseases (PIDs) in Korea. Here we attempted to estimate the PID epidemiology and disease burden in Korea. A systematic review was performed of studies retrieved from the PubMed, KoreaMed, and Google Scholar databases. Studies on PIDs published in Korean or English between January 2001 and November 2018 were analyzed. The number of PID patients and the healthcare costs were estimated from Health Insurance Review and Assessment Service (HIRA) Korea data for 2017. A total of 398 PID patients were identified from 101 reports. Immunodeficiencies affecting cellular and humoral immunity were reported in 11 patients, combined immunodeficiency with associated or syndromic features in 40, predominantly antibody deficiencies in 144, diseases of immune dysregulation in 58, congenital defects of phagocytes in 104, defects in the intrinsic and innate immunity in 1, auto-inflammatory disorders in 4, complement deficiencies in 36, and phenocopies of PID in none. From the HIRA reimbursement data, a total of 1,162 outpatients and 306 inpatients were treated for 8,166 and 6,149 days, respectively. In addition, reimbursement was requested for 8,200 outpatient and 1,090 inpatient cases and $1,924,000 and $4,715,000 were reimbursed in 2017, respectively. This study systematically reviewed published studies on PID and analyzed the national open data system of the HIRA to estimate the disease burden of PID, for the first time in Korea.
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spelling pubmed-80241172021-04-14 Systematic review of literature and analysis of big data from the National Health Insurance System on primary immunodeficiencies in Korea Son, Sohee Kang, Ji-Man Hahn, Younsoo Ahn, Kangmo Kim, Yae-Jean Clin Exp Pediatr Review Article There are very scant data on the epidemiology of primary immunodeficiency diseases (PIDs) in Korea. Here we attempted to estimate the PID epidemiology and disease burden in Korea. A systematic review was performed of studies retrieved from the PubMed, KoreaMed, and Google Scholar databases. Studies on PIDs published in Korean or English between January 2001 and November 2018 were analyzed. The number of PID patients and the healthcare costs were estimated from Health Insurance Review and Assessment Service (HIRA) Korea data for 2017. A total of 398 PID patients were identified from 101 reports. Immunodeficiencies affecting cellular and humoral immunity were reported in 11 patients, combined immunodeficiency with associated or syndromic features in 40, predominantly antibody deficiencies in 144, diseases of immune dysregulation in 58, congenital defects of phagocytes in 104, defects in the intrinsic and innate immunity in 1, auto-inflammatory disorders in 4, complement deficiencies in 36, and phenocopies of PID in none. From the HIRA reimbursement data, a total of 1,162 outpatients and 306 inpatients were treated for 8,166 and 6,149 days, respectively. In addition, reimbursement was requested for 8,200 outpatient and 1,090 inpatient cases and $1,924,000 and $4,715,000 were reimbursed in 2017, respectively. This study systematically reviewed published studies on PID and analyzed the national open data system of the HIRA to estimate the disease burden of PID, for the first time in Korea. Korean Pediatric Society 2020-07-13 /pmc/articles/PMC8024117/ /pubmed/32683811 http://dx.doi.org/10.3345/cep.2019.01347 Text en Copyright © 2021 by The Korean Pediatric Society This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Son, Sohee
Kang, Ji-Man
Hahn, Younsoo
Ahn, Kangmo
Kim, Yae-Jean
Systematic review of literature and analysis of big data from the National Health Insurance System on primary immunodeficiencies in Korea
title Systematic review of literature and analysis of big data from the National Health Insurance System on primary immunodeficiencies in Korea
title_full Systematic review of literature and analysis of big data from the National Health Insurance System on primary immunodeficiencies in Korea
title_fullStr Systematic review of literature and analysis of big data from the National Health Insurance System on primary immunodeficiencies in Korea
title_full_unstemmed Systematic review of literature and analysis of big data from the National Health Insurance System on primary immunodeficiencies in Korea
title_short Systematic review of literature and analysis of big data from the National Health Insurance System on primary immunodeficiencies in Korea
title_sort systematic review of literature and analysis of big data from the national health insurance system on primary immunodeficiencies in korea
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024117/
https://www.ncbi.nlm.nih.gov/pubmed/32683811
http://dx.doi.org/10.3345/cep.2019.01347
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