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Predictive factors of death in neonates with hypoxic-ischemic encephalopathy receiving selective head cooling

BACKGROUND: Severe perinatal asphyxia results in multiple organ involvement, neonate hospitalization, and eventual death. PURPOSE: This study aimed to investigate the predictive factors of death in newborns with hypoxic-ischemic encephalopathy (HIE) receiving selective head cooling. METHODS: This cr...

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Detalles Bibliográficos
Autores principales: Basiri, Behnaz, Sabzehei, Mohammadkazem, sabahi, Mohammadmahdi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Pediatric Society 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024121/
https://www.ncbi.nlm.nih.gov/pubmed/32882782
http://dx.doi.org/10.3345/cep.2019.01382
Descripción
Sumario:BACKGROUND: Severe perinatal asphyxia results in multiple organ involvement, neonate hospitalization, and eventual death. PURPOSE: This study aimed to investigate the predictive factors of death in newborns with hypoxic-ischemic encephalopathy (HIE) receiving selective head cooling. METHODS: This cross-sectional descriptive-retrospective study was conducted from 2013 to 2018 in Fatemieh Hospital of Hamadan and included 51 newborns who were admitted to the neonatal intensive care unit with a diagnosis of HIE. Selective head cooling for patients with moderate to severe HIE began within 6 hours of birth and continued for 72 hours. The required data for the predictive factors of death were extracted from the patients’ medical files, recorded on a premade form, and analyzed using SPSS ver. 16. RESULTS: Of the 51 neonates with moderate to severe HIE who were treated with selective head cooling, 16 (31%) died. There were significant relationships between death and the need for advanced neonatal resuscitation (P=0.002), need for mechanical ventilation (P=0.016), 1-minute Apgar score (P=0.040), and severely abnormal amplitude-integrated electroencephalography (a-EEG) (P=0.047). Multiple regression of variables or data showed that the need for advanced neonatal resuscitation was an independent predictive factor of death (P=0.0075) and severely abnormal a-EEG was an independent predictive factor of asphyxia severity (P=0.0001). CONCLUSION: All cases of neonatal death in our study were severe HIE (stage 3). Advanced neonatal resuscitation was an independent predictor of death, while a severely abnormal a-EEG was an independent predictor of asphyxia severity in infants with HIE.