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Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation
Thiazoline-related innate fear-eliciting compounds (tFOs) orchestrate hypothermia, hypometabolism, and anti-hypoxia, which enable survival in lethal hypoxic conditions. Here, we show that most of these effects are severely attenuated in transient receptor potential ankyrin 1 (Trpa1) knockout mice. T...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024280/ https://www.ncbi.nlm.nih.gov/pubmed/33824316 http://dx.doi.org/10.1038/s41467-021-22205-0 |
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author | Matsuo, Tomohiko Isosaka, Tomoko Hayashi, Yuichiro Tang, Lijun Doi, Akihiro Yasuda, Aiko Hayashi, Mikio Lee, Chia-Ying Cao, Liqin Kutsuna, Natsumaro Matsunaga, Sachihiro Matsuda, Takeshi Yao, Ikuko Setou, Mitsuyoshi Kanagawa, Dai Higasa, Koichiro Ikawa, Masahito Liu, Qinghua Kobayakawa, Reiko Kobayakawa, Ko |
author_facet | Matsuo, Tomohiko Isosaka, Tomoko Hayashi, Yuichiro Tang, Lijun Doi, Akihiro Yasuda, Aiko Hayashi, Mikio Lee, Chia-Ying Cao, Liqin Kutsuna, Natsumaro Matsunaga, Sachihiro Matsuda, Takeshi Yao, Ikuko Setou, Mitsuyoshi Kanagawa, Dai Higasa, Koichiro Ikawa, Masahito Liu, Qinghua Kobayakawa, Reiko Kobayakawa, Ko |
author_sort | Matsuo, Tomohiko |
collection | PubMed |
description | Thiazoline-related innate fear-eliciting compounds (tFOs) orchestrate hypothermia, hypometabolism, and anti-hypoxia, which enable survival in lethal hypoxic conditions. Here, we show that most of these effects are severely attenuated in transient receptor potential ankyrin 1 (Trpa1) knockout mice. TFO-induced hypothermia involves the Trpa1-mediated trigeminal/vagal pathways and non-Trpa1 olfactory pathway. TFOs activate Trpa1-positive sensory pathways projecting from trigeminal and vagal ganglia to the spinal trigeminal nucleus (Sp5) and nucleus of the solitary tract (NTS), and their artificial activation induces hypothermia. TFO presentation activates the NTS-Parabrachial nucleus pathway to induce hypothermia and hypometabolism; this activation was suppressed in Trpa1 knockout mice. TRPA1 activation is insufficient to trigger tFO-mediated anti-hypoxic effects; Sp5/NTS activation is also necessary. Accordingly, we find a novel molecule that enables mice to survive in a lethal hypoxic condition ten times longer than known tFOs. Combinations of appropriate tFOs and TRPA1 command intrinsic physiological responses relevant to survival fate. |
format | Online Article Text |
id | pubmed-8024280 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-80242802021-04-21 Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation Matsuo, Tomohiko Isosaka, Tomoko Hayashi, Yuichiro Tang, Lijun Doi, Akihiro Yasuda, Aiko Hayashi, Mikio Lee, Chia-Ying Cao, Liqin Kutsuna, Natsumaro Matsunaga, Sachihiro Matsuda, Takeshi Yao, Ikuko Setou, Mitsuyoshi Kanagawa, Dai Higasa, Koichiro Ikawa, Masahito Liu, Qinghua Kobayakawa, Reiko Kobayakawa, Ko Nat Commun Article Thiazoline-related innate fear-eliciting compounds (tFOs) orchestrate hypothermia, hypometabolism, and anti-hypoxia, which enable survival in lethal hypoxic conditions. Here, we show that most of these effects are severely attenuated in transient receptor potential ankyrin 1 (Trpa1) knockout mice. TFO-induced hypothermia involves the Trpa1-mediated trigeminal/vagal pathways and non-Trpa1 olfactory pathway. TFOs activate Trpa1-positive sensory pathways projecting from trigeminal and vagal ganglia to the spinal trigeminal nucleus (Sp5) and nucleus of the solitary tract (NTS), and their artificial activation induces hypothermia. TFO presentation activates the NTS-Parabrachial nucleus pathway to induce hypothermia and hypometabolism; this activation was suppressed in Trpa1 knockout mice. TRPA1 activation is insufficient to trigger tFO-mediated anti-hypoxic effects; Sp5/NTS activation is also necessary. Accordingly, we find a novel molecule that enables mice to survive in a lethal hypoxic condition ten times longer than known tFOs. Combinations of appropriate tFOs and TRPA1 command intrinsic physiological responses relevant to survival fate. Nature Publishing Group UK 2021-04-06 /pmc/articles/PMC8024280/ /pubmed/33824316 http://dx.doi.org/10.1038/s41467-021-22205-0 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Matsuo, Tomohiko Isosaka, Tomoko Hayashi, Yuichiro Tang, Lijun Doi, Akihiro Yasuda, Aiko Hayashi, Mikio Lee, Chia-Ying Cao, Liqin Kutsuna, Natsumaro Matsunaga, Sachihiro Matsuda, Takeshi Yao, Ikuko Setou, Mitsuyoshi Kanagawa, Dai Higasa, Koichiro Ikawa, Masahito Liu, Qinghua Kobayakawa, Reiko Kobayakawa, Ko Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation |
title | Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation |
title_full | Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation |
title_fullStr | Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation |
title_full_unstemmed | Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation |
title_short | Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation |
title_sort | thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory trpa1 activation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024280/ https://www.ncbi.nlm.nih.gov/pubmed/33824316 http://dx.doi.org/10.1038/s41467-021-22205-0 |
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