Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation

Thiazoline-related innate fear-eliciting compounds (tFOs) orchestrate hypothermia, hypometabolism, and anti-hypoxia, which enable survival in lethal hypoxic conditions. Here, we show that most of these effects are severely attenuated in transient receptor potential ankyrin 1 (Trpa1) knockout mice. T...

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Detalles Bibliográficos
Autores principales: Matsuo, Tomohiko, Isosaka, Tomoko, Hayashi, Yuichiro, Tang, Lijun, Doi, Akihiro, Yasuda, Aiko, Hayashi, Mikio, Lee, Chia-Ying, Cao, Liqin, Kutsuna, Natsumaro, Matsunaga, Sachihiro, Matsuda, Takeshi, Yao, Ikuko, Setou, Mitsuyoshi, Kanagawa, Dai, Higasa, Koichiro, Ikawa, Masahito, Liu, Qinghua, Kobayakawa, Reiko, Kobayakawa, Ko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024280/
https://www.ncbi.nlm.nih.gov/pubmed/33824316
http://dx.doi.org/10.1038/s41467-021-22205-0

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