ADCK1 activates the β-catenin/TCF signaling pathway to promote the growth and migration of colon cancer cells

As a result of mutations in the upstream components of the Wnt/β-catenin signaling pathway, this cascade is abnormally activated in colon cancer. Hence, identifying the activation mechanism of this pathway is an urgent need for the treatment of colon cancer. Here, we found an increase in ADCK1 (AarF...

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Autores principales: Ji, Yong, Liu, Yiqian, Sun, Changchun, Yu, Lijiang, Wang, Zhao, Du, Xu, Yang, Wu, Zhang, Chenggong, Tao, Chunmu, Wang, Jianjiang, Yang, Xi, Di, Sun, Huang, Yufeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024291/
https://www.ncbi.nlm.nih.gov/pubmed/33824271
http://dx.doi.org/10.1038/s41419-021-03624-9
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author Ji, Yong
Liu, Yiqian
Sun, Changchun
Yu, Lijiang
Wang, Zhao
Du, Xu
Yang, Wu
Zhang, Chenggong
Tao, Chunmu
Wang, Jianjiang
Yang, Xi
Di, Sun
Huang, Yufeng
author_facet Ji, Yong
Liu, Yiqian
Sun, Changchun
Yu, Lijiang
Wang, Zhao
Du, Xu
Yang, Wu
Zhang, Chenggong
Tao, Chunmu
Wang, Jianjiang
Yang, Xi
Di, Sun
Huang, Yufeng
author_sort Ji, Yong
collection PubMed
description As a result of mutations in the upstream components of the Wnt/β-catenin signaling pathway, this cascade is abnormally activated in colon cancer. Hence, identifying the activation mechanism of this pathway is an urgent need for the treatment of colon cancer. Here, we found an increase in ADCK1 (AarF domain-containing kinase 1) expression in clinical specimens of colon cancer and animal models. Upregulation of ADCK1 expression promoted the colony formation and infiltration of cancer cells. Downregulation of ADCK1 expression inhibited the colony formation and infiltration of cancer cells, in vivo tumorigenesis, migration, and organoid formation. Molecular mechanistic studies demonstrated that ADCK1 interacted with TCF4 (T-cell factor 4) to activate the β-catenin/TCF signaling pathway. In conclusion, our research revealed the functions of ADCK1 in the development of colon cancer and provided potential therapeutic targets.
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spelling pubmed-80242912021-04-21 ADCK1 activates the β-catenin/TCF signaling pathway to promote the growth and migration of colon cancer cells Ji, Yong Liu, Yiqian Sun, Changchun Yu, Lijiang Wang, Zhao Du, Xu Yang, Wu Zhang, Chenggong Tao, Chunmu Wang, Jianjiang Yang, Xi Di, Sun Huang, Yufeng Cell Death Dis Article As a result of mutations in the upstream components of the Wnt/β-catenin signaling pathway, this cascade is abnormally activated in colon cancer. Hence, identifying the activation mechanism of this pathway is an urgent need for the treatment of colon cancer. Here, we found an increase in ADCK1 (AarF domain-containing kinase 1) expression in clinical specimens of colon cancer and animal models. Upregulation of ADCK1 expression promoted the colony formation and infiltration of cancer cells. Downregulation of ADCK1 expression inhibited the colony formation and infiltration of cancer cells, in vivo tumorigenesis, migration, and organoid formation. Molecular mechanistic studies demonstrated that ADCK1 interacted with TCF4 (T-cell factor 4) to activate the β-catenin/TCF signaling pathway. In conclusion, our research revealed the functions of ADCK1 in the development of colon cancer and provided potential therapeutic targets. Nature Publishing Group UK 2021-04-06 /pmc/articles/PMC8024291/ /pubmed/33824271 http://dx.doi.org/10.1038/s41419-021-03624-9 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Ji, Yong
Liu, Yiqian
Sun, Changchun
Yu, Lijiang
Wang, Zhao
Du, Xu
Yang, Wu
Zhang, Chenggong
Tao, Chunmu
Wang, Jianjiang
Yang, Xi
Di, Sun
Huang, Yufeng
ADCK1 activates the β-catenin/TCF signaling pathway to promote the growth and migration of colon cancer cells
title ADCK1 activates the β-catenin/TCF signaling pathway to promote the growth and migration of colon cancer cells
title_full ADCK1 activates the β-catenin/TCF signaling pathway to promote the growth and migration of colon cancer cells
title_fullStr ADCK1 activates the β-catenin/TCF signaling pathway to promote the growth and migration of colon cancer cells
title_full_unstemmed ADCK1 activates the β-catenin/TCF signaling pathway to promote the growth and migration of colon cancer cells
title_short ADCK1 activates the β-catenin/TCF signaling pathway to promote the growth and migration of colon cancer cells
title_sort adck1 activates the β-catenin/tcf signaling pathway to promote the growth and migration of colon cancer cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024291/
https://www.ncbi.nlm.nih.gov/pubmed/33824271
http://dx.doi.org/10.1038/s41419-021-03624-9
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