Targeting nucleotide metabolism enhances the efficacy of anthracyclines and anti-metabolites in triple-negative breast cancer

Triple-negative breast cancer (TNBC) remains the most lethal breast cancer subtype with poor response rates to the current chemotherapies and a lack of additional effective treatment options. We have identified deoxyuridine 5′-triphosphate nucleotidohydrolase (dUTPase) as a critical gatekeeper that...

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Detalles Bibliográficos
Autores principales: Davison, Craig, Morelli, Roisin, Knowlson, Catherine, McKechnie, Melanie, Carson, Robbie, Stachtea, Xanthi, McLaughlin, Kylie A., Prise, Vivien E., Savage, Kienan, Wilson, Richard H., Mulligan, Karl A., Wilson, Peter M., Ladner, Robert D., LaBonte, Melissa J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024381/
https://www.ncbi.nlm.nih.gov/pubmed/33824328
http://dx.doi.org/10.1038/s41523-021-00245-5

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