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Choline supplementation prevents the effects of bilirubin on cerebellar mediated behavior in choline-restricted Gunn rat pups.
BACKGROUND: Bilirubin is produced by the breakdown of hemoglobin, and is normally catabolized and excreted. Neurotoxic accumulation of serum bilirubin often occurs in premature infants. The homozygous Gunn rat lacks uridine diphosphate-glucuronosyltransferase-1A1 (UGT1A1), the enzyme needed to biotr...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024424/ https://www.ncbi.nlm.nih.gov/pubmed/33027804 http://dx.doi.org/10.1038/s41390-020-01187-7 |