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Benefit of a pharmacist-led intervention for medication management of renal transplant patients: a controlled before-and-after study

AIMS: To assess the effect of a pharmacist-led intervention, using Barrows cards method, during the first year after renal transplantation, on patient knowledge about their treatment, medication adherence and exposure to treatment in a French cohort. METHODS: We conducted a before-and-after comparat...

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Autores principales: Chambord, Jeremy, Couzi, Lionel, Merville, Pierre, Moreau, Karine, Xuereb, Fabien, Djabarouti, Sarah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024450/
https://www.ncbi.nlm.nih.gov/pubmed/33868624
http://dx.doi.org/10.1177/20406223211005275
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author Chambord, Jeremy
Couzi, Lionel
Merville, Pierre
Moreau, Karine
Xuereb, Fabien
Djabarouti, Sarah
author_facet Chambord, Jeremy
Couzi, Lionel
Merville, Pierre
Moreau, Karine
Xuereb, Fabien
Djabarouti, Sarah
author_sort Chambord, Jeremy
collection PubMed
description AIMS: To assess the effect of a pharmacist-led intervention, using Barrows cards method, during the first year after renal transplantation, on patient knowledge about their treatment, medication adherence and exposure to treatment in a French cohort. METHODS: We conducted a before-and-after comparative study between two groups of patients: those who benefited from a complementary pharmacist-led intervention [intervention group (IG), n = 44] versus those who did not [control group (CG), n = 48]. The pharmacist-led intervention consisted of a behavioral and educational interview at the first visit (visit 1). The intervention was assessed 4 months later at the second visit (visit 2), using the following endpoints: treatment knowledge, medication adherence [proportion of days covered (PDC) by immunosuppressive therapy] and tacrolimus exposure. RESULTS: At visit 2, IG patients achieved a significantly higher knowledge score than CG patients (83.3% versus 72.2%, p = 0.001). We did not find any differences in treatment exposure or medication adherence; however, the intervention tended to reduce the proportion of non-adherent patients with low knowledge scores. Using the PDC by immunosuppressive therapy, we identified 10 non-adherent patients (10.9%) at visit 1 and six at visit 2. CONCLUSIONS: Our intervention showed a positive effect on patient knowledge about their treatment. However, our results did not show any improvement in overall medication adherence, which was likely to be because of the initially high level of adherence in our study population. Nevertheless, the intervention appears to have improved adherence in non-adherent patients with low knowledge scores.
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spelling pubmed-80244502021-04-16 Benefit of a pharmacist-led intervention for medication management of renal transplant patients: a controlled before-and-after study Chambord, Jeremy Couzi, Lionel Merville, Pierre Moreau, Karine Xuereb, Fabien Djabarouti, Sarah Ther Adv Chronic Dis Original Research AIMS: To assess the effect of a pharmacist-led intervention, using Barrows cards method, during the first year after renal transplantation, on patient knowledge about their treatment, medication adherence and exposure to treatment in a French cohort. METHODS: We conducted a before-and-after comparative study between two groups of patients: those who benefited from a complementary pharmacist-led intervention [intervention group (IG), n = 44] versus those who did not [control group (CG), n = 48]. The pharmacist-led intervention consisted of a behavioral and educational interview at the first visit (visit 1). The intervention was assessed 4 months later at the second visit (visit 2), using the following endpoints: treatment knowledge, medication adherence [proportion of days covered (PDC) by immunosuppressive therapy] and tacrolimus exposure. RESULTS: At visit 2, IG patients achieved a significantly higher knowledge score than CG patients (83.3% versus 72.2%, p = 0.001). We did not find any differences in treatment exposure or medication adherence; however, the intervention tended to reduce the proportion of non-adherent patients with low knowledge scores. Using the PDC by immunosuppressive therapy, we identified 10 non-adherent patients (10.9%) at visit 1 and six at visit 2. CONCLUSIONS: Our intervention showed a positive effect on patient knowledge about their treatment. However, our results did not show any improvement in overall medication adherence, which was likely to be because of the initially high level of adherence in our study population. Nevertheless, the intervention appears to have improved adherence in non-adherent patients with low knowledge scores. SAGE Publications 2021-04-05 /pmc/articles/PMC8024450/ /pubmed/33868624 http://dx.doi.org/10.1177/20406223211005275 Text en © The Author(s), 2021 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Research
Chambord, Jeremy
Couzi, Lionel
Merville, Pierre
Moreau, Karine
Xuereb, Fabien
Djabarouti, Sarah
Benefit of a pharmacist-led intervention for medication management of renal transplant patients: a controlled before-and-after study
title Benefit of a pharmacist-led intervention for medication management of renal transplant patients: a controlled before-and-after study
title_full Benefit of a pharmacist-led intervention for medication management of renal transplant patients: a controlled before-and-after study
title_fullStr Benefit of a pharmacist-led intervention for medication management of renal transplant patients: a controlled before-and-after study
title_full_unstemmed Benefit of a pharmacist-led intervention for medication management of renal transplant patients: a controlled before-and-after study
title_short Benefit of a pharmacist-led intervention for medication management of renal transplant patients: a controlled before-and-after study
title_sort benefit of a pharmacist-led intervention for medication management of renal transplant patients: a controlled before-and-after study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024450/
https://www.ncbi.nlm.nih.gov/pubmed/33868624
http://dx.doi.org/10.1177/20406223211005275
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