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Case Report: Molecular Diagnosis of Fungal Keratitis Associated With Contact Lenses Caused by Fusarium solani

Fusarium is a filamentous fungus commonly found in the environment and is the major cause of fungal keratitis. We report a case of keratomycosis caused by Fusarium solani in a patient using disposable soft contact lenses. A delay in diagnosis led to the initiation of an empirical antifungal treatmen...

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Autores principales: Trovato, Laura, Marino, Antonio, Pizzo, Giovanni, Oliveri, Salvatore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024464/
https://www.ncbi.nlm.nih.gov/pubmed/33842493
http://dx.doi.org/10.3389/fmed.2021.579516
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author Trovato, Laura
Marino, Antonio
Pizzo, Giovanni
Oliveri, Salvatore
author_facet Trovato, Laura
Marino, Antonio
Pizzo, Giovanni
Oliveri, Salvatore
author_sort Trovato, Laura
collection PubMed
description Fusarium is a filamentous fungus commonly found in the environment and is the major cause of fungal keratitis. We report a case of keratomycosis caused by Fusarium solani in a patient using disposable soft contact lenses. A delay in diagnosis led to the initiation of an empirical antifungal treatment with the subsequent deterioration of the patient's clinical condition. The use of the real-time quantitative PCR assay confirmed keratitis from F. solani providing a result in <48 h and therefore giving the possibility of quickly starting targeted antifungal therapy. The patient had an improvement in eye condition after the diagnosis of keratitis by F. solani and the rapid change to targeted antifungal treatment. For the rapid identification of corneal fungal pathogens, we believe that PCR may be added for the diagnosis of mycotic keratitis pending the isolation in culture that is necessary for in vitro susceptibility testing.
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spelling pubmed-80244642021-04-08 Case Report: Molecular Diagnosis of Fungal Keratitis Associated With Contact Lenses Caused by Fusarium solani Trovato, Laura Marino, Antonio Pizzo, Giovanni Oliveri, Salvatore Front Med (Lausanne) Medicine Fusarium is a filamentous fungus commonly found in the environment and is the major cause of fungal keratitis. We report a case of keratomycosis caused by Fusarium solani in a patient using disposable soft contact lenses. A delay in diagnosis led to the initiation of an empirical antifungal treatment with the subsequent deterioration of the patient's clinical condition. The use of the real-time quantitative PCR assay confirmed keratitis from F. solani providing a result in <48 h and therefore giving the possibility of quickly starting targeted antifungal therapy. The patient had an improvement in eye condition after the diagnosis of keratitis by F. solani and the rapid change to targeted antifungal treatment. For the rapid identification of corneal fungal pathogens, we believe that PCR may be added for the diagnosis of mycotic keratitis pending the isolation in culture that is necessary for in vitro susceptibility testing. Frontiers Media S.A. 2021-03-24 /pmc/articles/PMC8024464/ /pubmed/33842493 http://dx.doi.org/10.3389/fmed.2021.579516 Text en Copyright © 2021 Trovato, Marino, Pizzo and Oliveri. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Trovato, Laura
Marino, Antonio
Pizzo, Giovanni
Oliveri, Salvatore
Case Report: Molecular Diagnosis of Fungal Keratitis Associated With Contact Lenses Caused by Fusarium solani
title Case Report: Molecular Diagnosis of Fungal Keratitis Associated With Contact Lenses Caused by Fusarium solani
title_full Case Report: Molecular Diagnosis of Fungal Keratitis Associated With Contact Lenses Caused by Fusarium solani
title_fullStr Case Report: Molecular Diagnosis of Fungal Keratitis Associated With Contact Lenses Caused by Fusarium solani
title_full_unstemmed Case Report: Molecular Diagnosis of Fungal Keratitis Associated With Contact Lenses Caused by Fusarium solani
title_short Case Report: Molecular Diagnosis of Fungal Keratitis Associated With Contact Lenses Caused by Fusarium solani
title_sort case report: molecular diagnosis of fungal keratitis associated with contact lenses caused by fusarium solani
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024464/
https://www.ncbi.nlm.nih.gov/pubmed/33842493
http://dx.doi.org/10.3389/fmed.2021.579516
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