PPAR γ Prevents Neuropathic Pain by Down-Regulating CX3CR1 and Attenuating M1 Activation of Microglia in the Spinal Cord of Rats Using a Sciatic Chronic Constriction Injury Model

BACKGROUND: Previous studies have proved that peripheral nerve injury is involved in the pathogenesis of neuropathic pain (NP). The peripheral nerve injury primes spinal M1 microglia phenotype and produces pro-inflammatory cytokines, which are responsible for neurotoxic and neuronal hyper-excitable...

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Detalles Bibliográficos
Autores principales: Li, Xilei, Guo, Qulian, Ye, Zhi, Wang, E., Zou, Wangyuan, Sun, Zhihua, He, Zhenghua, Zhong, Tao, Weng, Yingqi, Pan, Yundan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024527/
https://www.ncbi.nlm.nih.gov/pubmed/33841075
http://dx.doi.org/10.3389/fnins.2021.620525

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