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Overcoming Chemoresistance via Extracellular Vesicle Inhibition

With the ever-growing number of cancer deaths worldwide, researchers have been working hard to identify the key reasons behind the failure of cancer therapies so the efficacy of those therapies may be improved. Based on extensive research activities and observations done by researchers, chemoresista...

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Autores principales: Hayatudin, Raeesah, Fong, Zhijack, Ming, Long Chiau, Goh, Bey-Hing, Lee, Wai-Leng, Kifli, Nurolaini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024536/
https://www.ncbi.nlm.nih.gov/pubmed/33842540
http://dx.doi.org/10.3389/fmolb.2021.629874
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author Hayatudin, Raeesah
Fong, Zhijack
Ming, Long Chiau
Goh, Bey-Hing
Lee, Wai-Leng
Kifli, Nurolaini
author_facet Hayatudin, Raeesah
Fong, Zhijack
Ming, Long Chiau
Goh, Bey-Hing
Lee, Wai-Leng
Kifli, Nurolaini
author_sort Hayatudin, Raeesah
collection PubMed
description With the ever-growing number of cancer deaths worldwide, researchers have been working hard to identify the key reasons behind the failure of cancer therapies so the efficacy of those therapies may be improved. Based on extensive research activities and observations done by researchers, chemoresistance has been identified as a major contributor to the drastic number of deaths among cancer patients. Several factors have been linked to formation of chemoresistance, such as chemotherapy drug efflux, immunosuppression, and epithelial-mesenchymal transition (EMT). Lately, increasing evidence has shed light on the role of extracellular vesicles (EVs) in the regulation of chemoresistance. However, there is limited research into the possibility that inhibiting EV release or uptake in cancer cells may curb chemoresistance, allowing chemotherapy drugs to target cancer cells without restriction. Prominent inhibitors of EV uptake and release in cancer cells have been compiled and contrasted in this review. This is in the hope of sparking greater interest in the field of EV-mediated chemoresistance, as well as to provide an overview of the field for fundamental and clinical research communities, particularly in the field of cancer resistance research. In-depth studies of EV-mediated chemoresistance and EV inhibitors in cancer cells would spur significant improvement in cancer treatments which are currently available.
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spelling pubmed-80245362021-04-08 Overcoming Chemoresistance via Extracellular Vesicle Inhibition Hayatudin, Raeesah Fong, Zhijack Ming, Long Chiau Goh, Bey-Hing Lee, Wai-Leng Kifli, Nurolaini Front Mol Biosci Molecular Biosciences With the ever-growing number of cancer deaths worldwide, researchers have been working hard to identify the key reasons behind the failure of cancer therapies so the efficacy of those therapies may be improved. Based on extensive research activities and observations done by researchers, chemoresistance has been identified as a major contributor to the drastic number of deaths among cancer patients. Several factors have been linked to formation of chemoresistance, such as chemotherapy drug efflux, immunosuppression, and epithelial-mesenchymal transition (EMT). Lately, increasing evidence has shed light on the role of extracellular vesicles (EVs) in the regulation of chemoresistance. However, there is limited research into the possibility that inhibiting EV release or uptake in cancer cells may curb chemoresistance, allowing chemotherapy drugs to target cancer cells without restriction. Prominent inhibitors of EV uptake and release in cancer cells have been compiled and contrasted in this review. This is in the hope of sparking greater interest in the field of EV-mediated chemoresistance, as well as to provide an overview of the field for fundamental and clinical research communities, particularly in the field of cancer resistance research. In-depth studies of EV-mediated chemoresistance and EV inhibitors in cancer cells would spur significant improvement in cancer treatments which are currently available. Frontiers Media S.A. 2021-03-24 /pmc/articles/PMC8024536/ /pubmed/33842540 http://dx.doi.org/10.3389/fmolb.2021.629874 Text en Copyright © 2021 Hayatudin, Fong, Ming, Goh, Lee and Kifli. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Hayatudin, Raeesah
Fong, Zhijack
Ming, Long Chiau
Goh, Bey-Hing
Lee, Wai-Leng
Kifli, Nurolaini
Overcoming Chemoresistance via Extracellular Vesicle Inhibition
title Overcoming Chemoresistance via Extracellular Vesicle Inhibition
title_full Overcoming Chemoresistance via Extracellular Vesicle Inhibition
title_fullStr Overcoming Chemoresistance via Extracellular Vesicle Inhibition
title_full_unstemmed Overcoming Chemoresistance via Extracellular Vesicle Inhibition
title_short Overcoming Chemoresistance via Extracellular Vesicle Inhibition
title_sort overcoming chemoresistance via extracellular vesicle inhibition
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024536/
https://www.ncbi.nlm.nih.gov/pubmed/33842540
http://dx.doi.org/10.3389/fmolb.2021.629874
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