Of Lymph Nodes and CLL Cells: Deciphering the Role of CCR7 in the Pathogenesis of CLL and Understanding Its Potential as Therapeutic Target

The lymph node (LN) is an essential tissue for achieving effective immune responses but it is also critical in the pathogenesis of chronic lymphocytic leukemia (CLL). Within the multitude of signaling pathways aberrantly regulated in CLL the homeostatic axis composed by the chemokine receptor CCR7 a...

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Autores principales: Cuesta-Mateos, Carlos, Brown, Jennifer R., Terrón, Fernando, Muñoz-Calleja, Cecilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024566/
https://www.ncbi.nlm.nih.gov/pubmed/33841445
http://dx.doi.org/10.3389/fimmu.2021.662866
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author Cuesta-Mateos, Carlos
Brown, Jennifer R.
Terrón, Fernando
Muñoz-Calleja, Cecilia
author_facet Cuesta-Mateos, Carlos
Brown, Jennifer R.
Terrón, Fernando
Muñoz-Calleja, Cecilia
author_sort Cuesta-Mateos, Carlos
collection PubMed
description The lymph node (LN) is an essential tissue for achieving effective immune responses but it is also critical in the pathogenesis of chronic lymphocytic leukemia (CLL). Within the multitude of signaling pathways aberrantly regulated in CLL the homeostatic axis composed by the chemokine receptor CCR7 and its ligands is the main driver for directing immune cells to home into the LN. In this literature review, we address the roles of CCR7 in the pathophysiology of CLL, and how this chemokine receptor is of critical importance to develop more rational and effective therapies for this malignancy.
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spelling pubmed-80245662021-04-08 Of Lymph Nodes and CLL Cells: Deciphering the Role of CCR7 in the Pathogenesis of CLL and Understanding Its Potential as Therapeutic Target Cuesta-Mateos, Carlos Brown, Jennifer R. Terrón, Fernando Muñoz-Calleja, Cecilia Front Immunol Immunology The lymph node (LN) is an essential tissue for achieving effective immune responses but it is also critical in the pathogenesis of chronic lymphocytic leukemia (CLL). Within the multitude of signaling pathways aberrantly regulated in CLL the homeostatic axis composed by the chemokine receptor CCR7 and its ligands is the main driver for directing immune cells to home into the LN. In this literature review, we address the roles of CCR7 in the pathophysiology of CLL, and how this chemokine receptor is of critical importance to develop more rational and effective therapies for this malignancy. Frontiers Media S.A. 2021-03-24 /pmc/articles/PMC8024566/ /pubmed/33841445 http://dx.doi.org/10.3389/fimmu.2021.662866 Text en Copyright © 2021 Cuesta-Mateos, Brown, Terrón and Muñoz-Calleja http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Cuesta-Mateos, Carlos
Brown, Jennifer R.
Terrón, Fernando
Muñoz-Calleja, Cecilia
Of Lymph Nodes and CLL Cells: Deciphering the Role of CCR7 in the Pathogenesis of CLL and Understanding Its Potential as Therapeutic Target
title Of Lymph Nodes and CLL Cells: Deciphering the Role of CCR7 in the Pathogenesis of CLL and Understanding Its Potential as Therapeutic Target
title_full Of Lymph Nodes and CLL Cells: Deciphering the Role of CCR7 in the Pathogenesis of CLL and Understanding Its Potential as Therapeutic Target
title_fullStr Of Lymph Nodes and CLL Cells: Deciphering the Role of CCR7 in the Pathogenesis of CLL and Understanding Its Potential as Therapeutic Target
title_full_unstemmed Of Lymph Nodes and CLL Cells: Deciphering the Role of CCR7 in the Pathogenesis of CLL and Understanding Its Potential as Therapeutic Target
title_short Of Lymph Nodes and CLL Cells: Deciphering the Role of CCR7 in the Pathogenesis of CLL and Understanding Its Potential as Therapeutic Target
title_sort of lymph nodes and cll cells: deciphering the role of ccr7 in the pathogenesis of cll and understanding its potential as therapeutic target
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024566/
https://www.ncbi.nlm.nih.gov/pubmed/33841445
http://dx.doi.org/10.3389/fimmu.2021.662866
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