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Fas/FasL Signaling Regulates CD8 Expression During Exposure to Self-Antigens

Activation of self-reactive CD8(+) T cells induces a peripheral tolerance mechanism that involves loss of CD8 expression. Because genetic deficiency of Fas and Fasl causes the accumulation of double-negative (DN; CD3(+) TCR-αβ(+) CD4(-) CD8(-)) T cells that have been proposed to derive from CD8(+) c...

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Detalles Bibliográficos
Autores principales:	Flores-Mendoza, Giovanna, Rodríguez-Rodríguez, Noé, Rubio, Rosa M., Madera-Salcedo, Iris K., Rosetti, Florencia, Crispín, José C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024570/ https://www.ncbi.nlm.nih.gov/pubmed/33841416 http://dx.doi.org/10.3389/fimmu.2021.635862

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