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The Role of the Transcription Factor EGR1 in Cancer
Early growth response factor 1 (EGR1) is a transcription factor that is mainly involved in the processes of tissue injury, immune responses, and fibrosis. Recent studies have shown that EGR1 is closely related to the initiation and progression of cancer and may participate in tumor cell proliferatio...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024650/ https://www.ncbi.nlm.nih.gov/pubmed/33842351 http://dx.doi.org/10.3389/fonc.2021.642547 |
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author | Wang, Bin Guo, Hanfei Yu, Hongquan Chen, Yong Xu, Haiyang Zhao, Gang |
author_facet | Wang, Bin Guo, Hanfei Yu, Hongquan Chen, Yong Xu, Haiyang Zhao, Gang |
author_sort | Wang, Bin |
collection | PubMed |
description | Early growth response factor 1 (EGR1) is a transcription factor that is mainly involved in the processes of tissue injury, immune responses, and fibrosis. Recent studies have shown that EGR1 is closely related to the initiation and progression of cancer and may participate in tumor cell proliferation, invasion, and metastasis and in tumor angiogenesis. Nonetheless, the specific mechanism whereby EGR1 modulates these processes remains to be elucidated. This review article summarizes possible mechanisms of action of EGR1 in tumorigenesis and tumor progression and may serve as a reference for clinical efficacy predictions and for the discovery of new therapeutic targets. |
format | Online Article Text |
id | pubmed-8024650 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80246502021-04-08 The Role of the Transcription Factor EGR1 in Cancer Wang, Bin Guo, Hanfei Yu, Hongquan Chen, Yong Xu, Haiyang Zhao, Gang Front Oncol Oncology Early growth response factor 1 (EGR1) is a transcription factor that is mainly involved in the processes of tissue injury, immune responses, and fibrosis. Recent studies have shown that EGR1 is closely related to the initiation and progression of cancer and may participate in tumor cell proliferation, invasion, and metastasis and in tumor angiogenesis. Nonetheless, the specific mechanism whereby EGR1 modulates these processes remains to be elucidated. This review article summarizes possible mechanisms of action of EGR1 in tumorigenesis and tumor progression and may serve as a reference for clinical efficacy predictions and for the discovery of new therapeutic targets. Frontiers Media S.A. 2021-03-24 /pmc/articles/PMC8024650/ /pubmed/33842351 http://dx.doi.org/10.3389/fonc.2021.642547 Text en Copyright © 2021 Wang, Guo, Yu, Chen, Xu and Zhao http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Wang, Bin Guo, Hanfei Yu, Hongquan Chen, Yong Xu, Haiyang Zhao, Gang The Role of the Transcription Factor EGR1 in Cancer |
title | The Role of the Transcription Factor EGR1 in Cancer |
title_full | The Role of the Transcription Factor EGR1 in Cancer |
title_fullStr | The Role of the Transcription Factor EGR1 in Cancer |
title_full_unstemmed | The Role of the Transcription Factor EGR1 in Cancer |
title_short | The Role of the Transcription Factor EGR1 in Cancer |
title_sort | role of the transcription factor egr1 in cancer |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024650/ https://www.ncbi.nlm.nih.gov/pubmed/33842351 http://dx.doi.org/10.3389/fonc.2021.642547 |
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