Cargando…

The Role of the Transcription Factor EGR1 in Cancer

Early growth response factor 1 (EGR1) is a transcription factor that is mainly involved in the processes of tissue injury, immune responses, and fibrosis. Recent studies have shown that EGR1 is closely related to the initiation and progression of cancer and may participate in tumor cell proliferatio...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Bin, Guo, Hanfei, Yu, Hongquan, Chen, Yong, Xu, Haiyang, Zhao, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024650/
https://www.ncbi.nlm.nih.gov/pubmed/33842351
http://dx.doi.org/10.3389/fonc.2021.642547
_version_ 1783675353377538048
author Wang, Bin
Guo, Hanfei
Yu, Hongquan
Chen, Yong
Xu, Haiyang
Zhao, Gang
author_facet Wang, Bin
Guo, Hanfei
Yu, Hongquan
Chen, Yong
Xu, Haiyang
Zhao, Gang
author_sort Wang, Bin
collection PubMed
description Early growth response factor 1 (EGR1) is a transcription factor that is mainly involved in the processes of tissue injury, immune responses, and fibrosis. Recent studies have shown that EGR1 is closely related to the initiation and progression of cancer and may participate in tumor cell proliferation, invasion, and metastasis and in tumor angiogenesis. Nonetheless, the specific mechanism whereby EGR1 modulates these processes remains to be elucidated. This review article summarizes possible mechanisms of action of EGR1 in tumorigenesis and tumor progression and may serve as a reference for clinical efficacy predictions and for the discovery of new therapeutic targets.
format Online
Article
Text
id pubmed-8024650
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-80246502021-04-08 The Role of the Transcription Factor EGR1 in Cancer Wang, Bin Guo, Hanfei Yu, Hongquan Chen, Yong Xu, Haiyang Zhao, Gang Front Oncol Oncology Early growth response factor 1 (EGR1) is a transcription factor that is mainly involved in the processes of tissue injury, immune responses, and fibrosis. Recent studies have shown that EGR1 is closely related to the initiation and progression of cancer and may participate in tumor cell proliferation, invasion, and metastasis and in tumor angiogenesis. Nonetheless, the specific mechanism whereby EGR1 modulates these processes remains to be elucidated. This review article summarizes possible mechanisms of action of EGR1 in tumorigenesis and tumor progression and may serve as a reference for clinical efficacy predictions and for the discovery of new therapeutic targets. Frontiers Media S.A. 2021-03-24 /pmc/articles/PMC8024650/ /pubmed/33842351 http://dx.doi.org/10.3389/fonc.2021.642547 Text en Copyright © 2021 Wang, Guo, Yu, Chen, Xu and Zhao http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Wang, Bin
Guo, Hanfei
Yu, Hongquan
Chen, Yong
Xu, Haiyang
Zhao, Gang
The Role of the Transcription Factor EGR1 in Cancer
title The Role of the Transcription Factor EGR1 in Cancer
title_full The Role of the Transcription Factor EGR1 in Cancer
title_fullStr The Role of the Transcription Factor EGR1 in Cancer
title_full_unstemmed The Role of the Transcription Factor EGR1 in Cancer
title_short The Role of the Transcription Factor EGR1 in Cancer
title_sort role of the transcription factor egr1 in cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024650/
https://www.ncbi.nlm.nih.gov/pubmed/33842351
http://dx.doi.org/10.3389/fonc.2021.642547
work_keys_str_mv AT wangbin theroleofthetranscriptionfactoregr1incancer
AT guohanfei theroleofthetranscriptionfactoregr1incancer
AT yuhongquan theroleofthetranscriptionfactoregr1incancer
AT chenyong theroleofthetranscriptionfactoregr1incancer
AT xuhaiyang theroleofthetranscriptionfactoregr1incancer
AT zhaogang theroleofthetranscriptionfactoregr1incancer
AT wangbin roleofthetranscriptionfactoregr1incancer
AT guohanfei roleofthetranscriptionfactoregr1incancer
AT yuhongquan roleofthetranscriptionfactoregr1incancer
AT chenyong roleofthetranscriptionfactoregr1incancer
AT xuhaiyang roleofthetranscriptionfactoregr1incancer
AT zhaogang roleofthetranscriptionfactoregr1incancer