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Adhesion G protein-coupled receptor VLGR1/ADGRV1 regulates cell spreading and migration by mechanosensing at focal adhesions

VLGR1 (very large G protein-coupled receptor-1) is by far the largest adhesion G protein-coupled receptor in humans. Homozygous pathologic variants of VLGR1 cause hereditary deaf blindness in Usher syndrome 2C and haploinsufficiency of VLGR1 is associated with epilepsy. However, its molecular functi...

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Detalles Bibliográficos
Autores principales:	Kusuluri, Deva K., Güler, Baran E., Knapp, Barbara, Horn, Nicola, Boldt, Karsten, Ueffing, Marius, Aust, Gabriela, Wolfrum, Uwe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024656/ https://www.ncbi.nlm.nih.gov/pubmed/33851099 http://dx.doi.org/10.1016/j.isci.2021.102283

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