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Identification of VIMP as a gene inhibiting cytokine production in human CD4+ effector T cells

Many players regulating the CD4(+) T cell-mediated inflammatory response have already been identified. However, the critical nodes that constitute the regulatory and signaling networks underlying CD4 T cell responses are still missing. Using a correlation-network-guided approach, here we identified...

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Autores principales: Capelle, Christophe M., Zeng, Ni, Danileviciute, Egle, Rodrigues, Sabrina Freitas, Ollert, Markus, Balling, Rudi, He, Feng Q.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024663/
https://www.ncbi.nlm.nih.gov/pubmed/33851102
http://dx.doi.org/10.1016/j.isci.2021.102289
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author Capelle, Christophe M.
Zeng, Ni
Danileviciute, Egle
Rodrigues, Sabrina Freitas
Ollert, Markus
Balling, Rudi
He, Feng Q.
author_facet Capelle, Christophe M.
Zeng, Ni
Danileviciute, Egle
Rodrigues, Sabrina Freitas
Ollert, Markus
Balling, Rudi
He, Feng Q.
author_sort Capelle, Christophe M.
collection PubMed
description Many players regulating the CD4(+) T cell-mediated inflammatory response have already been identified. However, the critical nodes that constitute the regulatory and signaling networks underlying CD4 T cell responses are still missing. Using a correlation-network-guided approach, here we identified VIMP (VCP-interacting membrane protein), one of the 25 genes encoding selenoproteins in humans, as a gene regulating the effector functions of human CD4 T cells, especially production of several cytokines including IL2 and CSF2. We identified VIMP as an endogenous inhibitor of cytokine production in CD4 effector T cells via both the E2F5 transcription regulatory pathway and the Ca(2+)/NFATC2 signaling pathway. Our work not only indicates that VIMP might be a promising therapeutic target for various inflammation-associated diseases but also shows that our network-guided approach can significantly aid in predicting new functions of the genes of interest.
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spelling pubmed-80246632021-04-12 Identification of VIMP as a gene inhibiting cytokine production in human CD4+ effector T cells Capelle, Christophe M. Zeng, Ni Danileviciute, Egle Rodrigues, Sabrina Freitas Ollert, Markus Balling, Rudi He, Feng Q. iScience Article Many players regulating the CD4(+) T cell-mediated inflammatory response have already been identified. However, the critical nodes that constitute the regulatory and signaling networks underlying CD4 T cell responses are still missing. Using a correlation-network-guided approach, here we identified VIMP (VCP-interacting membrane protein), one of the 25 genes encoding selenoproteins in humans, as a gene regulating the effector functions of human CD4 T cells, especially production of several cytokines including IL2 and CSF2. We identified VIMP as an endogenous inhibitor of cytokine production in CD4 effector T cells via both the E2F5 transcription regulatory pathway and the Ca(2+)/NFATC2 signaling pathway. Our work not only indicates that VIMP might be a promising therapeutic target for various inflammation-associated diseases but also shows that our network-guided approach can significantly aid in predicting new functions of the genes of interest. Elsevier 2021-03-09 /pmc/articles/PMC8024663/ /pubmed/33851102 http://dx.doi.org/10.1016/j.isci.2021.102289 Text en © 2021 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Capelle, Christophe M.
Zeng, Ni
Danileviciute, Egle
Rodrigues, Sabrina Freitas
Ollert, Markus
Balling, Rudi
He, Feng Q.
Identification of VIMP as a gene inhibiting cytokine production in human CD4+ effector T cells
title Identification of VIMP as a gene inhibiting cytokine production in human CD4+ effector T cells
title_full Identification of VIMP as a gene inhibiting cytokine production in human CD4+ effector T cells
title_fullStr Identification of VIMP as a gene inhibiting cytokine production in human CD4+ effector T cells
title_full_unstemmed Identification of VIMP as a gene inhibiting cytokine production in human CD4+ effector T cells
title_short Identification of VIMP as a gene inhibiting cytokine production in human CD4+ effector T cells
title_sort identification of vimp as a gene inhibiting cytokine production in human cd4+ effector t cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024663/
https://www.ncbi.nlm.nih.gov/pubmed/33851102
http://dx.doi.org/10.1016/j.isci.2021.102289
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