Cargando…
An experimental strategy to probe Gq contribution to signal transduction in living cells
Heterotrimeric G protein subunits Gαq and Gα11 are inhibited by two cyclic depsipeptides, FR900359 (FR) and YM-254890 (YM), both of which are being used widely to implicate Gq/11 proteins in the regulation of diverse biological processes. An emerging major research question therefore is whether the...
Autores principales: | Patt, Julian, Alenfelder, Judith, Pfeil, Eva Marie, Voss, Jan Hendrik, Merten, Nicole, Eryilmaz, Funda, Heycke, Nina, Rick, Uli, Inoue, Asuka, Kehraus, Stefan, Deupi, Xavier, Müller, Christa E., König, Gabriele M., Crüsemann, Max, Kostenis, Evi |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024710/ https://www.ncbi.nlm.nih.gov/pubmed/33639168 http://dx.doi.org/10.1016/j.jbc.2021.100472 |
Ejemplares similares
-
Thioesterase-mediated side chain transesterification generates potent Gq signaling inhibitor FR900359
por: Hermes, Cornelia, et al.
Publicado: (2021) -
Rational design of a heterotrimeric G protein α subunit with artificial inhibitor sensitivity
por: Malfacini, Davide, et al.
Publicado: (2019) -
The experimental power of FR900359 to study Gq-regulated biological processes
por: Schrage, Ramona, et al.
Publicado: (2015) -
Glucose-stimulated insulin secretion depends on FFA1 and Gq in neonatal mouse islets
por: Lorza-Gil, Estela, et al.
Publicado: (2023) -
Cyclopropane-Containing Fatty Acids from the Marine Bacterium Labrenzia sp. 011 with Antimicrobial and GPR84 Activity
por: Amiri Moghaddam, Jamshid, et al.
Publicado: (2018)