The RNA‐helicase DDX21 upregulates CEP55 expression and promotes neuroblastoma

Approximately 25% of human neuroblastoma is caused by amplification of the MYCN oncogene, which leads to overexpression of N‐Myc oncoprotein. The survival rate for this patient subtype is <50%. Here, we show that N‐Myc protein bound to the DEAD‐box RNA helicase DDX21 gene promoter and upregulated...

Descripción completa

Detalles Bibliográficos
Autores principales: Putra, Vina, Hulme, Amy J., Tee, Andrew E., Sun, Jane Q.J., Atmadibrata, Bernard, Ho, Nicholas, Chen, Jingwei, Gao, Jixuan, Norris, Murray D., Haber, Michelle, Kavallaris, Maria, Henderson, Michelle J., McCarroll, Joshua, Trahair, Toby, Liu, Tao, Liu, Pei Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024731/
https://www.ncbi.nlm.nih.gov/pubmed/33497018
http://dx.doi.org/10.1002/1878-0261.12906

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024731/
https://www.ncbi.nlm.nih.gov/pubmed/33497018
http://dx.doi.org/10.1002/1878-0261.12906

Ejemplares similares