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Common allotypes of ER aminopeptidase 1 have substrate-dependent and highly variable enzymatic properties

Polymorphic variation of immune system proteins can drive variability of individual immune responses. Endoplasmic reticulum aminopeptidase 1 (ERAP1) generates antigenic peptides for presentation by major histocompatibility complex class I molecules. Coding SNPs in ERAP1 have been associated with pre...

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Detalles Bibliográficos
Autores principales:	Hutchinson, Jonathan P., Temponeras, Ioannis, Kuiper, Jonas, Cortes, Adrian, Korczynska, Justyna, Kitchen, Semra, Stratikos, Efstratios
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024916/ https://www.ncbi.nlm.nih.gov/pubmed/33617882 http://dx.doi.org/10.1016/j.jbc.2021.100443

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