Spontaneous Regression of Blastic Plasmacytoid Dendritic Cell Neoplasm Following Sepsis by Serratia marcescens: A Case Report and Literature Review

Spontaneous regression is rare in patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN). An 85-year-old man presented with pancytopenia and skin lesions, and the bone marrow exhibited 79.6% CD4+, CD56+, CD123+, and TCL-1+ abnormal cells, with a normal karyotype; he was thus diagnosed wi...

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Detalles Bibliográficos
Autores principales: Suzuki, Akane, Abe, Shori, Koyama, Kaori, Suzuki, Shinju, Nagao, Munenori, Kobayashi, Masahiro, Nomura, Jun, Tsutsumi, Tomomi, Takeda, Tomoki, Oka, Yumiko, Shirota, Yuko, Takasawa, Naruhiko, Kodera, Takao, Okitsu, Yoko, Takahashi, Shinichiro, Ichinohasama, Ryo, Kameoka, Junichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024952/
https://www.ncbi.nlm.nih.gov/pubmed/33716255
http://dx.doi.org/10.2169/internalmedicine.5820-20
Descripción
Sumario:Spontaneous regression is rare in patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN). An 85-year-old man presented with pancytopenia and skin lesions, and the bone marrow exhibited 79.6% CD4+, CD56+, CD123+, and TCL-1+ abnormal cells, with a normal karyotype; he was thus diagnosed with BPDCN. While being followed without chemotherapy, he was admitted due to sepsis induced by Serratia marcescens, which was successfully treated with antibiotics. Notably, his blood cell counts improved, and the skin lesions disappeared. To our knowledge, this is the first reported case of spontaneous regression of BPDCN with a decrease in tumor cells in the bone marrow following sepsis.

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