p53-Independent Induction of p21 Fails to Control Regeneration and Hepatocarcinogenesis in a Murine Liver Injury Model

BACKGROUND & AIMS: A coordinated stress and regenerative response is important after hepatocyte damage. Here, we investigate the phenotypes that result from genetic abrogation of individual components of the checkpoint kinase 2/transformation-related protein 53 (p53)/cyclin-dependent kinase inhi...

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Detalles Bibliográficos
Autores principales: Buitrago-Molina, Laura Elisa, Marhenke, Silke, Becker, Diana, Geffers, Robert, Itzel, Timo, Teufel, Andreas, Jaeschke, Hartmut, Lechel, André, Unger, Kristian, Markovic, Jovana, Sharma, Amar Deep, Marquardt, Jens U., Saborowski, Michael, Saborowski, Anna, Vogel, Arndt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024980/
https://www.ncbi.nlm.nih.gov/pubmed/33484913
http://dx.doi.org/10.1016/j.jcmgh.2021.01.006

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