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Vascular smooth muscle lipofuscinosis occurring predominantly in veins of a cynomolgus monkey (Macaca fascicularis)
A 6-year-old male cynomolgus monkey showed chronic wasting. No gross abnormalities were observed in necropsy except for changes secondary to wasting. Microscopic examination revealed pigment granules deposition in systemic smooth muscles. They were observed as brown or basophilic in hematoxylin and...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Japanese Society of Veterinary Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8025426/ https://www.ncbi.nlm.nih.gov/pubmed/33504720 http://dx.doi.org/10.1292/jvms.20-0676 |
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author | SEKIYA, Akio KAWASAKO, Kazufumi DOI, Takuya |
author_facet | SEKIYA, Akio KAWASAKO, Kazufumi DOI, Takuya |
author_sort | SEKIYA, Akio |
collection | PubMed |
description | A 6-year-old male cynomolgus monkey showed chronic wasting. No gross abnormalities were observed in necropsy except for changes secondary to wasting. Microscopic examination revealed pigment granules deposition in systemic smooth muscles. They were observed as brown or basophilic in hematoxylin and eosin stain, and were positive for periodic acid-Schiff, Schmorl and Ziehl-Neelsen. Ultrastructurally, they consisted of residual bodies surrounded with varying amounts of solitary ribosomes. Thus, these granules were considered as lipofuscin. Unlike brown bowel syndrome in humans, the pigment granules were distributed systemically not only in the digestive tract but also in the blood vessels predominantly in the veins. To our knowledge, this is the first report on vascular smooth muscle lipofuscinosis occurring predominantly in the veins of primates. |
format | Online Article Text |
id | pubmed-8025426 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Japanese Society of Veterinary Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-80254262021-04-13 Vascular smooth muscle lipofuscinosis occurring predominantly in veins of a cynomolgus monkey (Macaca fascicularis) SEKIYA, Akio KAWASAKO, Kazufumi DOI, Takuya J Vet Med Sci Pathology A 6-year-old male cynomolgus monkey showed chronic wasting. No gross abnormalities were observed in necropsy except for changes secondary to wasting. Microscopic examination revealed pigment granules deposition in systemic smooth muscles. They were observed as brown or basophilic in hematoxylin and eosin stain, and were positive for periodic acid-Schiff, Schmorl and Ziehl-Neelsen. Ultrastructurally, they consisted of residual bodies surrounded with varying amounts of solitary ribosomes. Thus, these granules were considered as lipofuscin. Unlike brown bowel syndrome in humans, the pigment granules were distributed systemically not only in the digestive tract but also in the blood vessels predominantly in the veins. To our knowledge, this is the first report on vascular smooth muscle lipofuscinosis occurring predominantly in the veins of primates. The Japanese Society of Veterinary Science 2021-01-26 2021-03 /pmc/articles/PMC8025426/ /pubmed/33504720 http://dx.doi.org/10.1292/jvms.20-0676 Text en ©2021 The Japanese Society of Veterinary Science This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Pathology SEKIYA, Akio KAWASAKO, Kazufumi DOI, Takuya Vascular smooth muscle lipofuscinosis occurring predominantly in veins of a cynomolgus monkey (Macaca fascicularis) |
title | Vascular smooth muscle lipofuscinosis occurring predominantly in veins of a cynomolgus monkey (Macaca
fascicularis) |
title_full | Vascular smooth muscle lipofuscinosis occurring predominantly in veins of a cynomolgus monkey (Macaca
fascicularis) |
title_fullStr | Vascular smooth muscle lipofuscinosis occurring predominantly in veins of a cynomolgus monkey (Macaca
fascicularis) |
title_full_unstemmed | Vascular smooth muscle lipofuscinosis occurring predominantly in veins of a cynomolgus monkey (Macaca
fascicularis) |
title_short | Vascular smooth muscle lipofuscinosis occurring predominantly in veins of a cynomolgus monkey (Macaca
fascicularis) |
title_sort | vascular smooth muscle lipofuscinosis occurring predominantly in veins of a cynomolgus monkey (macaca
fascicularis) |
topic | Pathology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8025426/ https://www.ncbi.nlm.nih.gov/pubmed/33504720 http://dx.doi.org/10.1292/jvms.20-0676 |
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