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Vascular smooth muscle lipofuscinosis occurring predominantly in veins of a cynomolgus monkey (Macaca fascicularis)

A 6-year-old male cynomolgus monkey showed chronic wasting. No gross abnormalities were observed in necropsy except for changes secondary to wasting. Microscopic examination revealed pigment granules deposition in systemic smooth muscles. They were observed as brown or basophilic in hematoxylin and...

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Detalles Bibliográficos
Autores principales: SEKIYA, Akio, KAWASAKO, Kazufumi, DOI, Takuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8025426/
https://www.ncbi.nlm.nih.gov/pubmed/33504720
http://dx.doi.org/10.1292/jvms.20-0676
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author SEKIYA, Akio
KAWASAKO, Kazufumi
DOI, Takuya
author_facet SEKIYA, Akio
KAWASAKO, Kazufumi
DOI, Takuya
author_sort SEKIYA, Akio
collection PubMed
description A 6-year-old male cynomolgus monkey showed chronic wasting. No gross abnormalities were observed in necropsy except for changes secondary to wasting. Microscopic examination revealed pigment granules deposition in systemic smooth muscles. They were observed as brown or basophilic in hematoxylin and eosin stain, and were positive for periodic acid-Schiff, Schmorl and Ziehl-Neelsen. Ultrastructurally, they consisted of residual bodies surrounded with varying amounts of solitary ribosomes. Thus, these granules were considered as lipofuscin. Unlike brown bowel syndrome in humans, the pigment granules were distributed systemically not only in the digestive tract but also in the blood vessels predominantly in the veins. To our knowledge, this is the first report on vascular smooth muscle lipofuscinosis occurring predominantly in the veins of primates.
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spelling pubmed-80254262021-04-13 Vascular smooth muscle lipofuscinosis occurring predominantly in veins of a cynomolgus monkey (Macaca fascicularis) SEKIYA, Akio KAWASAKO, Kazufumi DOI, Takuya J Vet Med Sci Pathology A 6-year-old male cynomolgus monkey showed chronic wasting. No gross abnormalities were observed in necropsy except for changes secondary to wasting. Microscopic examination revealed pigment granules deposition in systemic smooth muscles. They were observed as brown or basophilic in hematoxylin and eosin stain, and were positive for periodic acid-Schiff, Schmorl and Ziehl-Neelsen. Ultrastructurally, they consisted of residual bodies surrounded with varying amounts of solitary ribosomes. Thus, these granules were considered as lipofuscin. Unlike brown bowel syndrome in humans, the pigment granules were distributed systemically not only in the digestive tract but also in the blood vessels predominantly in the veins. To our knowledge, this is the first report on vascular smooth muscle lipofuscinosis occurring predominantly in the veins of primates. The Japanese Society of Veterinary Science 2021-01-26 2021-03 /pmc/articles/PMC8025426/ /pubmed/33504720 http://dx.doi.org/10.1292/jvms.20-0676 Text en ©2021 The Japanese Society of Veterinary Science This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Pathology
SEKIYA, Akio
KAWASAKO, Kazufumi
DOI, Takuya
Vascular smooth muscle lipofuscinosis occurring predominantly in veins of a cynomolgus monkey (Macaca fascicularis)
title Vascular smooth muscle lipofuscinosis occurring predominantly in veins of a cynomolgus monkey (Macaca fascicularis)
title_full Vascular smooth muscle lipofuscinosis occurring predominantly in veins of a cynomolgus monkey (Macaca fascicularis)
title_fullStr Vascular smooth muscle lipofuscinosis occurring predominantly in veins of a cynomolgus monkey (Macaca fascicularis)
title_full_unstemmed Vascular smooth muscle lipofuscinosis occurring predominantly in veins of a cynomolgus monkey (Macaca fascicularis)
title_short Vascular smooth muscle lipofuscinosis occurring predominantly in veins of a cynomolgus monkey (Macaca fascicularis)
title_sort vascular smooth muscle lipofuscinosis occurring predominantly in veins of a cynomolgus monkey (macaca fascicularis)
topic Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8025426/
https://www.ncbi.nlm.nih.gov/pubmed/33504720
http://dx.doi.org/10.1292/jvms.20-0676
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