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Cholate Conjugated Polymeric Amphiphiles as Efficient Artificial Ionophores
[Image: see text] A family of amphiphilic copolymers containing hydrophobic cholate pendants has been prepared by copolymerization of cholic acid-based monomer 2-(methacryloxy)-ethyl cholate (MAECA) with polyethylene glycol methyl ether methacrylate (PEGMA). The polymers differ for the content of MA...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American
Chemical Society
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8025732/ https://www.ncbi.nlm.nih.gov/pubmed/33842888 http://dx.doi.org/10.1021/acsapm.0c01182 |
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author | Sahoo, Subhasish ur Rehman, Jawad Shah, Muhammad Raza De, Priyadarsi Tecilla, Paolo |
author_facet | Sahoo, Subhasish ur Rehman, Jawad Shah, Muhammad Raza De, Priyadarsi Tecilla, Paolo |
author_sort | Sahoo, Subhasish |
collection | PubMed |
description | [Image: see text] A family of amphiphilic copolymers containing hydrophobic cholate pendants has been prepared by copolymerization of cholic acid-based monomer 2-(methacryloxy)-ethyl cholate (MAECA) with polyethylene glycol methyl ether methacrylate (PEGMA). The polymers differ for the content of MAECA that increases from 0 to 35%. The copolymers partition within liposomes and display potent ionophoric activity forming large pores in the membrane and allowing the leakage of small inorganic ions (H(+), Na(+)) and of large polar organic molecules (calcein). Their activity is strictly correlated to the content of cholic acid subunits, increasing as the fraction of cholate moiety increases. |
format | Online Article Text |
id | pubmed-8025732 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | American
Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-80257322021-04-08 Cholate Conjugated Polymeric Amphiphiles as Efficient Artificial Ionophores Sahoo, Subhasish ur Rehman, Jawad Shah, Muhammad Raza De, Priyadarsi Tecilla, Paolo ACS Appl Polym Mater [Image: see text] A family of amphiphilic copolymers containing hydrophobic cholate pendants has been prepared by copolymerization of cholic acid-based monomer 2-(methacryloxy)-ethyl cholate (MAECA) with polyethylene glycol methyl ether methacrylate (PEGMA). The polymers differ for the content of MAECA that increases from 0 to 35%. The copolymers partition within liposomes and display potent ionophoric activity forming large pores in the membrane and allowing the leakage of small inorganic ions (H(+), Na(+)) and of large polar organic molecules (calcein). Their activity is strictly correlated to the content of cholic acid subunits, increasing as the fraction of cholate moiety increases. American Chemical Society 2021-01-04 2021-02-12 /pmc/articles/PMC8025732/ /pubmed/33842888 http://dx.doi.org/10.1021/acsapm.0c01182 Text en © 2021 American Chemical Society Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Sahoo, Subhasish ur Rehman, Jawad Shah, Muhammad Raza De, Priyadarsi Tecilla, Paolo Cholate Conjugated Polymeric Amphiphiles as Efficient Artificial Ionophores |
title | Cholate Conjugated Polymeric Amphiphiles as Efficient
Artificial Ionophores |
title_full | Cholate Conjugated Polymeric Amphiphiles as Efficient
Artificial Ionophores |
title_fullStr | Cholate Conjugated Polymeric Amphiphiles as Efficient
Artificial Ionophores |
title_full_unstemmed | Cholate Conjugated Polymeric Amphiphiles as Efficient
Artificial Ionophores |
title_short | Cholate Conjugated Polymeric Amphiphiles as Efficient
Artificial Ionophores |
title_sort | cholate conjugated polymeric amphiphiles as efficient
artificial ionophores |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8025732/ https://www.ncbi.nlm.nih.gov/pubmed/33842888 http://dx.doi.org/10.1021/acsapm.0c01182 |
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