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Management of the Elderly Patients with High-Grade Serous Ovarian Cancer in the REAL-WORLD Setting

Treatment of elderly patients with neoplasia is challenging. Age is a known prognostic factor in ovarian cancer but the optimal treatment of elderly patients has not been determined. We undertook a retrospective analysis to determine clinical practice in advanced-stage ovarian cancer patients older...

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Autores principales: Liontos, Michalis, Papatheodoridi, Alkistis, Andrikopoulou, Angeliki, Thomakos, Nikolaos, Haidopoulos, Dimitrios, Rodolakis, Alexandros, Zagouri, Flora, Bamias, Aristotelis, Dimopoulos, Meletios-Athanasios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8025751/
https://www.ncbi.nlm.nih.gov/pubmed/33800101
http://dx.doi.org/10.3390/curroncol28020110
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author Liontos, Michalis
Papatheodoridi, Alkistis
Andrikopoulou, Angeliki
Thomakos, Nikolaos
Haidopoulos, Dimitrios
Rodolakis, Alexandros
Zagouri, Flora
Bamias, Aristotelis
Dimopoulos, Meletios-Athanasios
author_facet Liontos, Michalis
Papatheodoridi, Alkistis
Andrikopoulou, Angeliki
Thomakos, Nikolaos
Haidopoulos, Dimitrios
Rodolakis, Alexandros
Zagouri, Flora
Bamias, Aristotelis
Dimopoulos, Meletios-Athanasios
author_sort Liontos, Michalis
collection PubMed
description Treatment of elderly patients with neoplasia is challenging. Age is a known prognostic factor in ovarian cancer but the optimal treatment of elderly patients has not been determined. We undertook a retrospective analysis to determine clinical practice in advanced-stage ovarian cancer patients older than 70 years of age. Methods: Medical records of women with high-grade serous ovarian cancer, stage III and IV were retrospectively analyzed. Results: A total of 735 patients were identified with a median age of 61.5 years. 22.4% among them were older than 70 years of age at diagnosis. First-line Progression-Free Survival (PFS) and Overall Survival (OS) were significantly worse in elderly patients in comparison to the younger ones [mPFS 11.3 months vs. 14.8 months, (p < 0.001) and mOS 30.2 months vs. 45.6 months (p < 0.001)]. However, elderly patients were characterized by worse ECOG-Performance Status and they were more frequently treated with Neoadjuvant Chemotherapy followed by Interval Debulking Surgery, while often they were more frequently denied debulking surgery compared to patients under 70 years of age. Moreover, elderly patients received more frequently monotherapy with platinum as frontline treatment. In contrast, there was no significant difference in the outcome of the debulking surgery in comparison to the younger patients or the frequency that gBRCA test was performed. Age over 70 years did not retain its significance for either Progression-Free Survival or Overall Survival when adjusted for all other reported prognostic factors. Conclusions: Elderly ovarian cancer patients have a worse prognosis. Comprehensive geriatric assessment should be performed for the optimal treatment of these patients.
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spelling pubmed-80257512021-04-08 Management of the Elderly Patients with High-Grade Serous Ovarian Cancer in the REAL-WORLD Setting Liontos, Michalis Papatheodoridi, Alkistis Andrikopoulou, Angeliki Thomakos, Nikolaos Haidopoulos, Dimitrios Rodolakis, Alexandros Zagouri, Flora Bamias, Aristotelis Dimopoulos, Meletios-Athanasios Curr Oncol Article Treatment of elderly patients with neoplasia is challenging. Age is a known prognostic factor in ovarian cancer but the optimal treatment of elderly patients has not been determined. We undertook a retrospective analysis to determine clinical practice in advanced-stage ovarian cancer patients older than 70 years of age. Methods: Medical records of women with high-grade serous ovarian cancer, stage III and IV were retrospectively analyzed. Results: A total of 735 patients were identified with a median age of 61.5 years. 22.4% among them were older than 70 years of age at diagnosis. First-line Progression-Free Survival (PFS) and Overall Survival (OS) were significantly worse in elderly patients in comparison to the younger ones [mPFS 11.3 months vs. 14.8 months, (p < 0.001) and mOS 30.2 months vs. 45.6 months (p < 0.001)]. However, elderly patients were characterized by worse ECOG-Performance Status and they were more frequently treated with Neoadjuvant Chemotherapy followed by Interval Debulking Surgery, while often they were more frequently denied debulking surgery compared to patients under 70 years of age. Moreover, elderly patients received more frequently monotherapy with platinum as frontline treatment. In contrast, there was no significant difference in the outcome of the debulking surgery in comparison to the younger patients or the frequency that gBRCA test was performed. Age over 70 years did not retain its significance for either Progression-Free Survival or Overall Survival when adjusted for all other reported prognostic factors. Conclusions: Elderly ovarian cancer patients have a worse prognosis. Comprehensive geriatric assessment should be performed for the optimal treatment of these patients. MDPI 2021-03-07 /pmc/articles/PMC8025751/ /pubmed/33800101 http://dx.doi.org/10.3390/curroncol28020110 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Liontos, Michalis
Papatheodoridi, Alkistis
Andrikopoulou, Angeliki
Thomakos, Nikolaos
Haidopoulos, Dimitrios
Rodolakis, Alexandros
Zagouri, Flora
Bamias, Aristotelis
Dimopoulos, Meletios-Athanasios
Management of the Elderly Patients with High-Grade Serous Ovarian Cancer in the REAL-WORLD Setting
title Management of the Elderly Patients with High-Grade Serous Ovarian Cancer in the REAL-WORLD Setting
title_full Management of the Elderly Patients with High-Grade Serous Ovarian Cancer in the REAL-WORLD Setting
title_fullStr Management of the Elderly Patients with High-Grade Serous Ovarian Cancer in the REAL-WORLD Setting
title_full_unstemmed Management of the Elderly Patients with High-Grade Serous Ovarian Cancer in the REAL-WORLD Setting
title_short Management of the Elderly Patients with High-Grade Serous Ovarian Cancer in the REAL-WORLD Setting
title_sort management of the elderly patients with high-grade serous ovarian cancer in the real-world setting
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8025751/
https://www.ncbi.nlm.nih.gov/pubmed/33800101
http://dx.doi.org/10.3390/curroncol28020110
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