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Presence of allele CYP3A4*16 does not have any bearing on carbamazepine-induced adverse drug reactions in North Indian people with epilepsy

OBJECTIVES: The objectives of this study were to determine the relationship between genetic polymorphisms in gene encodings for CYP3A4 and carbamazepine (CBZ)-induced dose-related side effects in North Indian people with epilepsy. PATIENTS AND METHODS: The current prospective study included 37 patie...

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Autores principales: Garg, Vivek Kumar, Goyal, Manoj Kumar, Khullar, Madhu, Saikia, Biman, Medhi, Bikash, Prakash, Ajay, Prabhat, Nandita, Tandyala, Naresh, Mahesh, Karthik Vinay, Kharbanda, Parampreet S., Prabhakar, Sudesh, Modi, Manish, Lal, Vivek, Shree, Ritu, Sachdeva, Julie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8025771/
https://www.ncbi.nlm.nih.gov/pubmed/33283769
http://dx.doi.org/10.4103/ijp.IJP_549_20
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author Garg, Vivek Kumar
Goyal, Manoj Kumar
Khullar, Madhu
Saikia, Biman
Medhi, Bikash
Prakash, Ajay
Prabhat, Nandita
Tandyala, Naresh
Mahesh, Karthik Vinay
Kharbanda, Parampreet S.
Prabhakar, Sudesh
Modi, Manish
Lal, Vivek
Shree, Ritu
Sachdeva, Julie
author_facet Garg, Vivek Kumar
Goyal, Manoj Kumar
Khullar, Madhu
Saikia, Biman
Medhi, Bikash
Prakash, Ajay
Prabhat, Nandita
Tandyala, Naresh
Mahesh, Karthik Vinay
Kharbanda, Parampreet S.
Prabhakar, Sudesh
Modi, Manish
Lal, Vivek
Shree, Ritu
Sachdeva, Julie
author_sort Garg, Vivek Kumar
collection PubMed
description OBJECTIVES: The objectives of this study were to determine the relationship between genetic polymorphisms in gene encodings for CYP3A4 and carbamazepine (CBZ)-induced dose-related side effects in North Indian people with epilepsy. PATIENTS AND METHODS: The current prospective study included 37 patients with CBZ-induced dose-related side effects and 102 patients who did not experience side effects while on CBZ. The genotyping for CYP3A4 allele (CYP3A4*16) was done using real-time polymerase chain reaction (RT-PCR) in Applied Biosystems 7500 RT-PCR System (USA). CBZ was administered in all patients at a dose varying from 15 to 20 mg/kg daily. RESULTS: Various demographic variables were comparable between the groups except that control of seizures was far better in controls. After testing, it was found that none of our patients had the presence of CYP3A4*16 allele. CONCLUSION: CYP3A4*16 allele is not represented significantly in North Indian people with CBZ-induced dose-related side effects.
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spelling pubmed-80257712021-04-08 Presence of allele CYP3A4*16 does not have any bearing on carbamazepine-induced adverse drug reactions in North Indian people with epilepsy Garg, Vivek Kumar Goyal, Manoj Kumar Khullar, Madhu Saikia, Biman Medhi, Bikash Prakash, Ajay Prabhat, Nandita Tandyala, Naresh Mahesh, Karthik Vinay Kharbanda, Parampreet S. Prabhakar, Sudesh Modi, Manish Lal, Vivek Shree, Ritu Sachdeva, Julie Indian J Pharmacol Clinical Research Article OBJECTIVES: The objectives of this study were to determine the relationship between genetic polymorphisms in gene encodings for CYP3A4 and carbamazepine (CBZ)-induced dose-related side effects in North Indian people with epilepsy. PATIENTS AND METHODS: The current prospective study included 37 patients with CBZ-induced dose-related side effects and 102 patients who did not experience side effects while on CBZ. The genotyping for CYP3A4 allele (CYP3A4*16) was done using real-time polymerase chain reaction (RT-PCR) in Applied Biosystems 7500 RT-PCR System (USA). CBZ was administered in all patients at a dose varying from 15 to 20 mg/kg daily. RESULTS: Various demographic variables were comparable between the groups except that control of seizures was far better in controls. After testing, it was found that none of our patients had the presence of CYP3A4*16 allele. CONCLUSION: CYP3A4*16 allele is not represented significantly in North Indian people with CBZ-induced dose-related side effects. Wolters Kluwer - Medknow 2020 2020-12-05 /pmc/articles/PMC8025771/ /pubmed/33283769 http://dx.doi.org/10.4103/ijp.IJP_549_20 Text en Copyright: © 2020 Indian Journal of Pharmacology http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Clinical Research Article
Garg, Vivek Kumar
Goyal, Manoj Kumar
Khullar, Madhu
Saikia, Biman
Medhi, Bikash
Prakash, Ajay
Prabhat, Nandita
Tandyala, Naresh
Mahesh, Karthik Vinay
Kharbanda, Parampreet S.
Prabhakar, Sudesh
Modi, Manish
Lal, Vivek
Shree, Ritu
Sachdeva, Julie
Presence of allele CYP3A4*16 does not have any bearing on carbamazepine-induced adverse drug reactions in North Indian people with epilepsy
title Presence of allele CYP3A4*16 does not have any bearing on carbamazepine-induced adverse drug reactions in North Indian people with epilepsy
title_full Presence of allele CYP3A4*16 does not have any bearing on carbamazepine-induced adverse drug reactions in North Indian people with epilepsy
title_fullStr Presence of allele CYP3A4*16 does not have any bearing on carbamazepine-induced adverse drug reactions in North Indian people with epilepsy
title_full_unstemmed Presence of allele CYP3A4*16 does not have any bearing on carbamazepine-induced adverse drug reactions in North Indian people with epilepsy
title_short Presence of allele CYP3A4*16 does not have any bearing on carbamazepine-induced adverse drug reactions in North Indian people with epilepsy
title_sort presence of allele cyp3a4*16 does not have any bearing on carbamazepine-induced adverse drug reactions in north indian people with epilepsy
topic Clinical Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8025771/
https://www.ncbi.nlm.nih.gov/pubmed/33283769
http://dx.doi.org/10.4103/ijp.IJP_549_20
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